{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:17:19Z","timestamp":1790140639532,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771389"],"award-info":[{"award-number":["81771389"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Bone metabolism can be influenced by a range of factors. We selected children with self\u2010limited epilepsy with centrotemporal spikes (SeLECTS) and lifestyles similar to those of healthy children to control for the confounding factors that may influence bone metabolism. We aimed to identify the specific effects of epilepsy and\/or anti\u2010seizure medications (ASMs) on bone metabolism.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with SeLECTS were divided into an untreated group and a monotherapy group, and the third group was a healthy control group. We determined the levels of various biochemical markers of bone metabolism, including procollagen type I nitrogenous propeptide (PINP), alkaline phosphatase (ALP), osteocalcin (OC), collagen type I cross\u2010linked C\u2010telopeptide (CTX), calcium, magnesium, phosphorus, parathyroid hormone (PTH), and vitamin D\n 3<\/jats:sub>\n (VD\n 3<\/jats:sub>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 1487 patients (from 19 centers) were diagnosed with SeLECTS; 1032 were analyzed, including 117 patients who did not receive any ASMs (untreated group), 643 patients who received only one ASM (monotherapy group), and 272 children in the healthy control group. Except for VD\n 3<\/jats:sub>\n , other bone metabolism of the three groups were\n different<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u2009<\u2009.001). Bone metabolism was significantly lower in the untreated group than the healthy control group\n (p<\/jats:italic>\n \u2009<\u2009.05). There were significant differences between the monotherapy and healthy control group in the level of many markers. However, when comparing the monotherapy and untreated groups, the results were different; oxcarbazepine, levetiracetam, and topiramate had no significant effect on bone metabolism. Phosphorus and magnesium were significantly lower in the valproic acid group than the untreated group (adjusted\n p<\/jats:italic>\n \u2009<\u2009.05, Cliff's delta .282\u2013.768). CTX was significantly higher in the lamotrigine group than in the untreated group (adjusted\n p<\/jats:italic>\n \u2009=\u2009.012, Cliff's delta\u2009=\u2009.316).\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n Epilepsy can affect many aspects of bone metabolism. After controlling epilepsy and other confounders that affect bone metabolism, we found that the effects of ASMs on bone metabolism differed. Oxcarbazepine, levetiracetam, and topiramate did not affect bone metabolism, and lamotrigine corrected some of the abnormal markers of bone metabolism in patients with epilepsy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/epi.17733","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T06:55:02Z","timestamp":1690786502000},"page":"2667-2678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Both epilepsy and anti\u2010seizure medications affect bone metabolism in children with self\u2010limited epilepsy with centrotemporal spikes"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-0900","authenticated-orcid":false,"given":"Xiu\u2010Yu","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, the First Medical Center Chinese PLA General Hospital Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Hong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Children's Hospital Tongji Medical College, Huazhong University of Science & Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u2010Fei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Children's Hospital Tongji Medical College, Huazhong University of Science & Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Children's Hospital Tongji Medical College, Huazhong University of Science & Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Children's Hospital\/Tianjin University Children's Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5506-2029","authenticated-orcid":false,"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Children's Hospital\/Tianjin University Children's Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics People's Hospital of Zhengzhou University, Henan Provincial People's Hospital Zhengzhou 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