{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:57:28Z","timestamp":1790909848817,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022184","name":"Institut Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022184","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nodular heterotopia (NH)\u2013related drug\u2010resistant epilepsy is challenging due to the deep location of the NH and the complexity of the underlying epileptogenic network. Using ictal stereo\u2010electroencephalography (SEEG) and functional connectivity (FC) analyses in 14 patients with NH\u2010related drug\u2010resistant epilepsy, we aimed to determine the leading structure during seizures. For this purpose, we compared node IN and OUT strength between bipolar channels inside the heterotopia and inside gray matter, at the group level and at the individual level. At seizure onset, the channels within NH belonging to the epileptogenic and\/or propagation network showed higher node OUT\u2010strength than the channels within the gray matter (<jats:italic>p<\/jats:italic>\u2009=\u2009.03), with higher node OUT\u2010strength than node IN\u2010strength (<jats:italic>p<\/jats:italic>\u2009=\u2009.03). These results are in favor of a \u201cleading\u201d role of NH during seizure onset when involved in the epileptogenic\u2010 or propagation\u2010zone network (50% of patients). However, when looking at the individual level, no significant difference between NH and gray matter was found, except for one patient (in two of three seizures). This result confirms the heterogeneity and the complexity of the epileptogenic network organization in NH and the need for SEEG exploration to characterize more precisely patient\u2010specific epileptogenic network organization.<\/jats:p>","DOI":"10.1111\/epi.17891","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T14:24:48Z","timestamp":1707747888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>Stereo\u2010EEG<\/scp>\u2013based ictal functional connectivity in patients with periventricular nodular heterotopia\u2013related epilepsy"],"prefix":"10.1111","volume":"65","author":[{"given":"Marc","family":"Zanello","sequence":"first","affiliation":[{"name":"Service de Neurochirurgie GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne  Paris France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, IMA\u2010BRAIN Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-4369","authenticated-orcid":false,"given":"Elodie","family":"Garnier","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Carron","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Stereotactic and Functional Neurosurgery  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Jegou","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-1302","authenticated-orcid":false,"given":"Stanislas","family":"Lagarde","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-2942","authenticated-orcid":false,"given":"Julia","family":"Makhalova","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"},{"name":"APHM La Timone, CEMEREM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Medina","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian\u2010G.","family":"B\u00e9nar","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-0297","authenticated-orcid":false,"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6345-1288","authenticated-orcid":false,"given":"Francesca","family":"Pizzo","sequence":"additional","affiliation":[{"name":"INSERM, INS, Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille University  Marseille France"},{"name":"APHM, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.182.2.1732969"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"1273","article-title":"Periventricular and subcortical nodular heterotopia. 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