{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:15:08Z","timestamp":1789578908463,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Status epilepticus (SE) may lead to long\u2010term consequences. This study evaluated the risk and predictors of seizure occurrence after SE, with a focus on SE due to acute symptomatic etiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospectively collected data about adults surviving a first non\u2010hypoxic SE were reviewed. The outcome was the occurrence of unprovoked seizures during the follow\u2010up. Kaplan\u2013Meier survival curve analysis and log\u2010rank test were used to analyze the time to seizure occurrence and determine the statistical significance between etiological groups. Three subcategories within acute etiology were considered according to the presence of the following: (1) structural lesion (acute\u2010primary); (2) brain involvement during systemic disorders (acute\u2010secondary); and (3) drug or alcohol intoxication\/withdrawal (acute\u2010toxic). Cox proportional hazards model was adopted to estimate hazard ratios (HRs) with the 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundreds fifty\u2010seven individuals were included. Fifty\u2010four subjects (21.0%) developed seizures after a median of 9.9 (interquartile range 4.3\u201321.7) months after SE. The estimated 1\u2010, 2\u2010, and 5\u2010year rates of seizure occurrence according to acute SE etiologies were 19.4%, 23.4%, and 30.1%, respectively, for acute\u2010primary central nervous system (CNS) pathology; 2.2%, 2.2%, and 8.7%, respectively, for acute\u2010secondary CNS pathology; and 0%, 9.1%, and 9.1%, respectively, for acute\u2010toxic causes. Five\u2010year rates of seizure occurrence for non\u2010acute SE causes were 33.9% for remote, 65.7% for progressive, and 25.9% for unknown etiologies. In multivariate Cox regression model, progressive etiology (adjusted HR [\n                      <jats:sub>adj<\/jats:sub>\n                      HR]\u20092.27, 95% CI 1.12\u20134.58), SE with prominent motor phenomena evolving in non\u2010convulsive SE (\n                      <jats:sub>adj<\/jats:sub>\n                      HR 3.17, 95% CI 1.38\u20137.25), and non\u2010convulsive SE (\n                      <jats:sub>adj<\/jats:sub>\n                      HR\u20092.38, 95% CI 1.16\u20134.90) were independently associated with higher hazards of unprovoked seizures. Older people (\n                      <jats:sub>adj<\/jats:sub>\n                      HR\u2009.98, 95% CI .96\u2013.99) and people with SE due to acute\u2010secondary CNS pathology (\n                      <jats:sub>adj<\/jats:sub>\n                      HR\u2009.18, 95% CI .04\u2013.82) were at decreased risk of seizure occurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>SE carries a risk of subsequent seizures. Both the underlying cause and epileptogenic effects of SE are likely to contribute.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17912","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T07:29:03Z","timestamp":1707550143000},"page":"1006-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The risk of unprovoked seizure occurrence after status epilepticus in adults"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-0083","authenticated-orcid":false,"given":"Simona","family":"Lattanzi","sequence":"first","affiliation":[{"name":"Neurological Clinic, Department of Experimental and Clinical Medicine Marche Polytechnic University  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-7363","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Neurology Unit, OCB Hospital AOU Modena  Modena Italy"},{"name":"Department of Biomedical, Metabolic and Neural Science, Center for Neuroscience and Neurotechnology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-5872","authenticated-orcid":false,"given":"Giada","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Neurology Unit, OCB Hospital AOU Modena  Modena Italy"},{"name":"PhD Program in Clinical and Experimental Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-1577","authenticated-orcid":false,"given":"Francesco","family":"Brigo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Science University of Verona  Verona Italy"},{"name":"Division of Neurology \u201cFranz Tappeiner\u201d Hospital  Merano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-2692","authenticated-orcid":false,"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurointensive Care, and Neurorehabilitation, Christian Doppler University Hospital Paracelsus Medical University, Member of EpiCARE  Salzburg Austria"},{"name":"Neuroscience Institute, Center for Cognitive Neuroscience Christian Doppler University Hospital Salzburg  Salzburg Austria"},{"name":"Public Health, Health Services Research and HTA University for Health Sciences, Medical Informatics and Technology  Hall i.T Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-539X","authenticated-orcid":false,"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Neurology Unit, OCB Hospital AOU Modena  Modena Italy"},{"name":"Department of Biomedical, Metabolic and Neural Science, Center for Neuroscience and Neurotechnology University of Modena and Reggio Emilia  Modena 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