{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:51:59Z","timestamp":1781085119431,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug\u2010resistant mesial temporal lobe epilepsy (MTLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective multicenter study included patients who underwent MTLE surgery at 19 expert centers on five continents. Benchmarks were defined for 15 endpoints covering surgery and epilepsy outcome at discharge, 1\u2009year after surgery, and the last available follow\u2010up. Patients were risk\u2010stratified by applying outcome\u2010relevant comorbidities, and benchmarks were calculated for low\u2010risk (\u201cbenchmark\u201d) cases. Respective measures were derived from the median value at each center, and the 75th percentile was considered the benchmark cutoff.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1119 patients with a mean age (range) of 36.7 (1\u201374) years and a male\u2010to\u2010female ratio of 1:1.1 were included. Most patients (59.2%) underwent anterior temporal lobe resection with amygdalohippocampectomy. The overall rate of complications or neurological deficits was 14.4%, with no in\u2010hospital death. After risk stratification, 377 (33.7%) benchmark cases of 1119 patients were identified, representing 13.6%\u201372.9% of cases per center and leaving 742 patients in the high\u2010risk cohort. Benchmark cutoffs for any complication, clinically apparent stroke, and reoperation rate at discharge were \u226424.6%, \u2264.5%, and \u22643.9%, respectively. A favorable seizure outcome (defined as International League Against Epilepsy class I and II) was reached in 83.6% at 1\u2009year and 79.0% at the last follow\u2010up in benchmark cases, leading to benchmark cutoffs of \u226575.2% (1\u2010year follow\u2010up) and \u226569.5% (mean follow\u2010up of 39.0\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study presents internationally applicable benchmark outcomes for the efficacy and safety of MTLE surgery. It may allow for comparison between centers, patient registries, and novel surgical and interventional techniques.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17923","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T12:28:55Z","timestamp":1708777735000},"page":"1333-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Defining benchmark outcomes for mesial temporal lobe epilepsy surgery: A global multicenter analysis of 1119 cases"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-3671","authenticated-orcid":false,"given":"Richard","family":"Drexler","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz L.","family":"Ricklefs","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharona","family":"Ben\u2010Haim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of California, San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-0786","authenticated-orcid":false,"given":"Anna","family":"Rada","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School Bielefeld University  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"W\u00f6rmann","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School Bielefeld University  Bielefeld 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