{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:02:23Z","timestamp":1791522143094,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Animal and human studies have shown that the seizure\u2010generating region is vastly dependent on distant neuronal hubs that can decrease duration and propagation of ongoing seizures. However, we still lack a comprehensive understanding of the impact of distant brain areas on specific interictal and ictal epileptic activities (e.g., isolated spikes, spike trains, seizures). Such knowledge is critically needed, because all kinds of epileptic activities are not equivalent in terms of clinical expression and impact on the progression of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used surface high\u2010density electroencephalography and multisite intracortical recordings, combined with pharmacological silencing of specific brain regions in the well\u2010known kainate mouse model of temporal lobe epilepsy. We tested the impact of selective regional silencing on the generation of epileptic activities within a continuum ranging from very transient to more sustained and long\u2010lasting discharges reminiscent of seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Silencing the contralateral hippocampus completely suppresses sustained ictal activities in the focus, as efficiently as silencing the focus itself, but whereas focus silencing abolishes all focus activities, contralateral silencing fails to control transient spikes. In parallel, we observed that sustained focus epileptiform discharges in the focus are preceded by contralateral firing and more strongly phase\u2010locked to bihippocampal delta\/theta oscillations than transient spiking activities, reinforcing the presumed dominant role of the contralateral hippocampus in promoting long\u2010lasting, but not transient, epileptic activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Altogether, our work provides suggestive evidence that the contralateral hippocampus is necessary for the interictal to ictal state transition and proposes that crosstalk between contralateral neuronal activity and ipsilateral delta\/theta oscillation could be a candidate mechanism underlying the progression from short\u2010 to long\u2010lasting epileptic activities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17970","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:03:57Z","timestamp":1715954637000},"page":"2082-2098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Involvement of the contralateral hippocampus in ictal\u2010like but not interictal epileptic activities in the kainate mouse model of temporal lobe epilepsy"],"prefix":"10.1111","volume":"65","author":[{"given":"Guru Prasad","family":"Padmasola","sequence":"first","affiliation":[{"name":"Functional Brain Mapping Lab, Department of Basic Neuroscience University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Friscourt","sequence":"additional","affiliation":[{"name":"Functional Brain Mapping Lab, Department of Basic Neuroscience University of Geneva  Geneva Switzerland"},{"name":"Neurosurgery Clinic, 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