{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:19:24Z","timestamp":1789532364176,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["36867"],"award-info":[{"award-number":["36867"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["43209"],"award-info":[{"award-number":["43209"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Acute magnetic resonance imaging (MRI) was obtained within a mean of 4.4 (SD\u2009=\u20095.5, median\u2009=\u20092.0) days after febrile status on &gt;200 infants with follow\u2010up MRI at approximately 1, 5, and 10\u2009years. Hippocampal size, morphology, and T2 signal intensity were scored visually by neuroradiologists blinded to clinical details. Hippocampal volumetry provided quantitative measurement. Upon the occurrence of two or more unprovoked seizures, subjects were reassessed for epilepsy. Hippocampal volumes were normalized using total brain volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen of 22 subjects with acute hippocampal T2 hyperintensity returned for follow\u2010up MRI, and 10 developed definite hippocampal sclerosis, which persisted through the 10\u2010year follow\u2010up. Hippocampi appearing normal initially remained normal on visual inspection. However, in subjects with normal\u2010appearing hippocampi, volumetrics indicated that male, but not female, hippocampi were smaller than controls, but increasing hippocampal asymmetry was not seen following febrile status. Forty\u2010four subjects developed epilepsy; six developed mesial temporal lobe epilepsy and, of the six, two had definite, two had equivocal, and two had no hippocampal sclerosis. Only one subject developed mesial temporal epilepsy without initial hyperintensity, and that subject had hippocampal malrotation. Ten\u2010year cumulative incidence of all types of epilepsy, including mesial temporal epilepsy, was highest in subjects with initial T2 hyperintensity and lowest in those with normal signal and no other brain abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Hippocampal T2 hyperintensity following febrile status epilepticus predicted hippocampal sclerosis and significant likelihood of mesial temporal lobe epilepsy. Normal hippocampal appearance in the acute postictal MRI was followed by maintained normal appearance, symmetric growth, and lower risk of epilepsy. Volumetric measurement detected mildly decreased hippocampal volume in males with febrile status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17979","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T05:30:36Z","timestamp":1712899836000},"page":"1568-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The\n                    <scp>FEBSTAT<\/scp>\n                    study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-7822","authenticated-orcid":false,"given":"Darrell V.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Pediatrics (Neurology) Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Voyvodic","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Shinnar","sequence":"additional","affiliation":[{"name":"Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Department of Pediatrics, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Harlem Hospital Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Radiology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9427-9476","authenticated-orcid":false,"given":"Solomon L.","family":"Mosh\u00e9","sequence":"additional","affiliation":[{"name":"Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Departments of Neuroscience and Pediatrics Albert Einstein College of Medicine, and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Douglas R.","family":"Nordli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Child Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Matthew","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of the King's Daughters and Eastern Virginia Medical School  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Pellock","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical College of Virginia, Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1783-5381","authenticated-orcid":false,"given":"Dale C.","family":"Hesdorffer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, G. H. Sergievsky Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neurology) Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth C.","family":"Shinnar","sequence":"additional","affiliation":[{"name":"Isabelle Rapin Division of Child Neurology, Saul R. 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Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Masur","sequence":"additional","affiliation":[{"name":"Department of Neurology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gallentine","sequence":"additional","affiliation":[{"name":"Stanford University Lucile Packard Children's Hospital  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0726-7547","authenticated-orcid":false,"given":"Erica","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Neurology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York 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