{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:39Z","timestamp":1772160279964,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K01 HD083759"],"award-info":[{"award-number":["K01 HD083759"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD099397"],"award-info":[{"award-number":["R01 HD099397"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Seizures can be difficult to control in infants and toddlers. Seizures with periods of apnea and hypoventilation are common following severe traumatic brain injury (TBI). We previously observed that brief apnea with hypoventilation (A&amp;H) in our severe TBI model acutely interrupted seizures. The current study is designed to determine the effect of A&amp;H on subsequent seizures and whether A&amp;H has potential therapeutic implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Piglets (1\u2009week or 1\u2009month old) received multifactorial injuries: cortical impact, mass effect, subdural hematoma, subarachnoid hemorrhage, and seizures induced with kainic acid. A&amp;H (1\u2009min apnea, 10\u2009min hypoventilation) was induced either before or after seizure induction, or control piglets received subdural\/subarachnoid hematoma and seizure without A&amp;H. In an intensive care unit, piglets were sedated, intubated, and mechanically ventilated, and epidural electroencephalogram was recorded for an average of 18\u2009h after seizure induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our severe TBI model, A&amp;H after seizure reduced ipsilateral seizure burden by 80% compared to the same injuries without A&amp;H. In the A&amp;H before seizure induction group, more piglets had exclusively contralateral seizures, although most piglets in all groups had seizures that shifted location throughout the several hours of seizure. After 8\u201310\u2009h, seizures transitioned to interictal epileptiform discharges regardless of A&amp;H or timing of A&amp;H.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Even brief A&amp;H may alter traumatic seizures. In our preclinical model, we will address the possibility of hypercapnia with normoxia, with controlled intracranial pressure, as a therapeutic option for children with status epilepticus after hemorrhagic TBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17993","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T10:36:26Z","timestamp":1715855786000},"page":"2099-2110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brief apnea with hypoventilation reduces seizure duration and shifts seizure location for several hours in a model of severe traumatic brain injury"],"prefix":"10.1111","volume":"65","author":[{"given":"Frances","family":"Rodriguez\u00a0Lara","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts 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