{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:43:51Z","timestamp":1772030631914,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201021\u2010CE14\u20100036"],"award-info":[{"award-number":["ANR\u201021\u2010CE14\u20100036"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because of its involvement in breathing control and neuronal excitability, dysregulation of the serotonin (5\u2010HT) 2C receptor (5\u2010HT2C) might play a key role in sudden unexpected death in epilepsy. Seizure\u2010induced respiratory arrest is thus prevented by a 5\u2010HT2B\/C agonist in different seizure model. However, the specific contribution of 5\u2010HT2C in chronic epilepsy\u2010related respiratory dysfunction remains unknown. In a rat model of temporal lobe epilepsy (EPI rats), in which we previously reported interictal respiratory dysfunctions and a reduction of brainstem 5\u2010HT tone, quantitative reverse transcriptase polymerase chain reaction showed overexpression of TPH2 (5\u2010HT synthesis enzyme), SERT (5\u2010HT reuptake transporter), and 5\u2010HT2C transcript levels in the brainstem of EPI rats, and of RNA\u2010specific adenosine deaminase (ADAR1, ADAR2) involved in the production of 5\u2010HT2C isoforms. Interictal ventilation was assessed with whole\u2010body plethysmography before and 2\u2009h after administration of SB242084 (2\u2009mg\/kg), a specific antagonist of 5\u2010HT2C. As expected, SB242084 administration induced a progressive decrease in ventilatory parameters and an alteration of breathing stability in both control and EPI rats. However, the size of the SB242084 effect was lower in EPI rats than in controls. Increased 5\u2010HT2C gene expression in the brainstem of EPI rats could be part of a compensatory mechanism against epilepsy\u2010related low 5\u2010HT tone and expression of 5\u2010HT2C isoforms for which 5\u2010HT affinity might be lower.<\/jats:p>","DOI":"10.1111\/epi.18006","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:09:20Z","timestamp":1715605760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-0645","authenticated-orcid":false,"given":"Hayet","family":"Kouchi","sequence":"first","affiliation":[{"name":"Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292 Lyon 1 University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathon","family":"Smith","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292 Lyon 1 University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Georges","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292 Lyon 1 University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freya","family":"Cracknell","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292 Lyon 1 University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-4267","authenticated-orcid":false,"given":"Laurent","family":"Bezin","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292 Lyon 1 University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-8515","authenticated-orcid":false,"given":"Sylvain","family":"Rheims","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292 Lyon 1 University  Lyon France"},{"name":"Department of Functional Neurology and Epileptology Hospices Civils de Lyon and Lyon 1 University  Lyon 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