{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:18:18Z","timestamp":1783041498511,"version":"3.54.6"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U48 DP006404\u201003S7"],"award-info":[{"award-number":["U48 DP006404\u201003S7"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Prior studies have examined chronic conditions in older adults with prevalent epilepsy, but rarely among those with incident epilepsy. Identifying the chronic conditions with which older adults present at epilepsy incidence assists with the evaluation of disease burden in this patient population and informs coordinated care development. The aim of this study was to identify preexisting chronic conditions with excess prevalence in older adults with incident epilepsy compared to those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a random sample of 4\u2009999\u2009999 fee\u2010for\u2010service Medicare beneficiaries aged &gt;65\u2009years, we conducted a retrospective cohort study of epilepsy incidence in 2019. Non\u2010Hispanic Black and Hispanic beneficiaries were oversampled. We identified preexisting chronic conditions from the 2016\u20132018 Medicare Beneficiary Summary Files and compared chronic condition prevalence between Medicare beneficiaries with and without incident epilepsy in 2019. We characterized variations in preexisting excess chronic condition prevalence by age, sex, and race\/ethnicity, adjusting for the racial\/ethnic oversampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed excess prevalence of most preexisting chronic conditions in beneficiaries with incident epilepsy (<jats:italic>n<\/jats:italic>\u2009=\u200920\u2009545, weighted <jats:italic>n<\/jats:italic>\u2009=\u200919\u2009631). For stroke, for example, the adjusted prevalence rate ratio (APRR) was 4.82 (99% CI:4.60, 5.04), meaning that, compared to those without epilepsy, beneficiaries with incident epilepsy in 2019 had 4.82 times the stroke prevalence. Similarly, beneficiaries with incident epilepsy had a higher prevalence rate for preexisting neurological conditions (APRR\u2009=\u20093.17, 99% CI =\u20093.08\u20133.27), substance use disorders (APRR\u2009=\u20093.00, 99% CI =\u20092.81\u20133.19), and psychiatric disorders (APRR\u2009=\u20091.98, 99% CI =\u20091.94\u20132.01). For most documented chronic conditions, excess prevalence among beneficiaries with incident epilepsy in 2019 was larger for younger age groups compared to older age groups, and for Hispanic beneficiaries compared to both non\u2010Hispanic White and non\u2010Hispanic Black beneficiaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Compared to epilepsy\u2010free Medicare beneficiaries, those with incident epilepsy in 2019 had a higher prevalence of most preexisting chronic conditions. Our findings highlight the importance of health promotion and prevention, multidisciplinary care, and elucidating shared pathophysiology to identify opportunities for prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18032","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:07:51Z","timestamp":1717520871000},"page":"2354-2367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Excess prevalence of preexisting chronic conditions in older adults with incident epilepsy"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-9581","authenticated-orcid":false,"given":"Siran M.","family":"Koroukian","sequence":"first","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5907-3951","authenticated-orcid":false,"given":"Hannah L.","family":"Fein","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-9732","authenticated-orcid":false,"given":"Wyatt P.","family":"Bensken","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-6477","authenticated-orcid":false,"given":"Nicholas K.","family":"Schiltz","sequence":"additional","affiliation":[{"name":"Frances Payne Bolton School of Nursing Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-668X","authenticated-orcid":false,"given":"Martha","family":"Sajatovic","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-2868","authenticated-orcid":false,"given":"Gena R.","family":"Ghearing","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Iowa Hospitals &amp; Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8658-2237","authenticated-orcid":false,"given":"David F.","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Sociology University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Center for Family &amp; Demographic Research Bowling Green State University  Bowling Green Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33064-8"},{"key":"e_1_2_10_3_1","volume-title":"Current population reports, P25\u20101144","author":"Vespa J","year":"2020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2021.11.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0714980809990390"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxs009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1993.tb02586.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003662"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1986.tb03567.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16991"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2008.10.013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)00225\u20102"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.11.013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2012.03500.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20685"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.7.731"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201671"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2010.02927.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17108"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1935"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.03.009"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12649"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5042"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.10.035"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2008.02124.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.05.005"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0b013e318293e1b4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0b013e3182477edc"},{"key":"e_1_2_10_29_1","unstructured":"Chronic conditions data warehouse.Data Dictionaries.2023.https:\/\/www2.ccwdata.org\/web\/guest\/data\u2010dictionaries. Accessed 8 Nov 2023"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2020.106414"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/mlr.0000000000001216"},{"key":"e_1_2_10_32_1","volume-title":"Stata statistical software: release 17","author":"StataCorp LLC","year":"2021"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000001680"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19546"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0027\u20109684(15)31299\u20102"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40615\u2010018\u20100478\u2010x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010074390"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.05.044"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.06.013"},{"key":"e_1_2_10_40_1","first-page":"101","volume-title":"International Review of Neurobiology","author":"Nunes PT","year":"2019"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161115666171116151051"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010019\u20100957\u20104"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13813"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.11.022"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.05.009"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.10.008"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.109770"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0895\u20104356(00)00363\u20102"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.2165\/11535570\u2010000000000\u201000000"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T10:50:05Z","timestamp":1723200605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/epi.18032"],"URL":"https:\/\/doi.org\/10.1111\/epi.18032","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2023-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}