{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:17:02Z","timestamp":1788599822801,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Research on cerebrovascular events in atrial fibrillation (AF) patients taking non\u2010vitamin K antagonist oral anticoagulants (NOACs) with antiseizure medications (ASMs) is limited, highlighting a significant gap in literature. We assessed thrombotic and hemorrhagic risks in patients on NOACs and ASMs versus those on NOACs or ASMs alone. We analyzed a retrospective cohort from five centers, including AF and epilepsy patients on both medications (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009188), AF patients on NOACs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009298), and epilepsy patients on ASMs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200950), with a 3\u2010year follow\u2010up. Propensity score matching adjusted for cardiovascular risk differences. The primary outcomes were ischemic stroke, transient ischemic attack, and major bleeding. Results showed the ASM+NOAC group had a higher risk of primary outcomes compared to the NOAC\u2010only group (5.68% vs. 1.18%, hazard ratio\u2009=\u20095.72, 95% confidence interval\u2009=\u20092.22\u201314.73), with no events in the ASM\u2010only group. This suggests an increased risk for patients on combined NOAC and ASM therapy, underlining the need for careful drug interaction consideration.\n                  <\/jats:p>","DOI":"10.1111\/epi.18039","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T11:37:36Z","timestamp":1718710656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and efficacy of concomitant treatment with non\u2010vitamin K antagonist oral anticoagulants and antiseizure medications: A propensity score matching cohort study"],"prefix":"10.1111","volume":"65","author":[{"given":"Michela","family":"Giustozzi","sequence":"first","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Calvello","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Medicine and Surgery, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Medicine and Surgery, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9623-1900","authenticated-orcid":false,"given":"Federico","family":"Paolini\u00a0Paoletti","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Medicine and Surgery, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Silvestrelli","sequence":"additional","affiliation":[{"name":"Neurology Clinic and Stroke Unit ASST  Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Mazzetti","sequence":"additional","affiliation":[{"name":"Internal Medicine, Careggi Hospital University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Silla","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Medicine and Surgery, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Bellotti","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Medicine and Surgery, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Vedovati","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Becattini","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-8543","authenticated-orcid":false,"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Neurology Clinic and Stroke Unit, Department of Neuroscience Bufalini Hospital  Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Medicine and Surgery, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, Santa Maria Della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-4221","authenticated-orcid":false,"given":"Cinzia","family":"Costa","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Medicine and Surgery, Santa Maria Della Misericordia Hospital University of Perugia  Perugia 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