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Beyond 1 year postoperatively, the influence of preoperative clinical factors on episodic memory and long\u2010term network plasticity remain underexplored. Ten years post\u2010ATLR, we aimed to determine biomarkers of successful memory network reorganization and establish presurgical features' lasting impact on memory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five ATLR patients (12 left\u2010sided) and 10 healthy controls underwent a memory\u2010encoding functional magnetic resonance imaging paradigm alongside neuropsychometry 10\u2009years postsurgery. Generalized psychophysiological interaction analyses modeled network functional connectivity of words\/faces remembered, seeding from the medial temporal lobes (MTLs). Differences in successful memory connectivity were assessed between controls and left\/right ATLR. Multivariate regressions and mixed\u2010effect models probed preoperative phenotypes' effects on long\u2010term memory outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten years post\u2010ATLR, lower baseline functioning (verbal and performance intelligence quotient) and a focal memory impairment preoperatively predicted worse long\u2010term memory outcomes. Poorer verbal memory was significantly associated with longer epilepsy duration and earlier onset age. Relative to controls, successful word and face encoding involved increased functional connectivity from both or remnant MTL seeds and contralesional parahippocampus\/hippocampus after left\/right ATLR. Irrespective of surgical laterality, successful memory encoding correlated with increased MTL\u2010seeded connectivity to frontal (bilateral insula, right anterior cingulate), right parahippocampal, and bilateral fusiform gyri. Ten years postsurgery, better memory performance was correlated with contralateral frontal plasticity, which was disrupted with longer epilepsy duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our findings underscore the enduring nature of functional network reorganizations to provide long\u2010term cognitive support. Ten years post\u2010ATLR, successful memory formation featured stronger connections near resected areas and contralateral regions. Preoperative network disruption possibly influenced effectiveness of postoperative plasticity. These findings are crucial for enhancing long\u2010term memory prediction and strategies for lasting memory rehabilitation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18058","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T13:56:22Z","timestamp":1720706182000},"page":"2641-2661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictors of long\u2010term memory and network connectivity 10\u2009years after anterior temporal lobe resection"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-0322","authenticated-orcid":false,"given":"Marine N.","family":"Fleury","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London UK"},{"name":"MRI Unit Epilepsy Society  Buckinghamshire 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