{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:40:19Z","timestamp":1789332019094,"version":"build-2803163510"},"reference-count":143,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R61NS133273"],"award-info":[{"award-number":["1R61NS133273"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Voltage\u2010gated potassium channels are expressed throughout the human body and are essential for physiological functions. These include delayed rectifiers, A\u2010type channels, outward rectifiers, and inward rectifiers. They impact electrical function in the heart (repolarization) and brain (repolarization and stabilization of the resting membrane potential).\n                    <jats:italic>KCNQx<\/jats:italic>\n                    and\n                    <jats:italic>KCNHx<\/jats:italic>\n                    encode K\n                    <jats:sub>v<\/jats:sub>\n                    7.x and K\n                    <jats:sub>v<\/jats:sub>\n                    11.x proteins, which form delayed rectifier potassium channels.\n                    <jats:italic>KCNQx<\/jats:italic>\n                    and\n                    <jats:italic>KCNHx<\/jats:italic>\n                    channelopathies are associated with both cardiac and neuronal pathologies. These include electrocardiographic abnormalities, cardiac arrhythmias, sudden cardiac death (SCD), epileptiform discharges, seizures, bipolar disorder, and sudden unexpected death in epilepsy (SUDEP). Due to the ubiquitous expression of\n                    <jats:italic>KCNQx<\/jats:italic>\n                    and\n                    <jats:italic>KCNHx<\/jats:italic>\n                    channels, abnormalities in their function can be particularly harmful, increasing the risk of sudden death. For example,\n                    <jats:italic>KCNH2<\/jats:italic>\n                    variants have a dual role in both cardiac and neuronal pathologies, whereas\n                    <jats:italic>KCNQ2<\/jats:italic>\n                    and\n                    <jats:italic>KCNQ3<\/jats:italic>\n                    variants are associated with severe and refractory epilepsy. Recurrent and uncontrolled seizures lead to secondary abnormalities, which include autonomics, cardiac electrical function, respiratory drive, and neuronal electrical activity. Even with a wide array of anti\u2010seizure therapies available on the market, one\u2010third of the more than 70 million people worldwide with epilepsy have uncontrolled seizures (i.e., intractable\/drug\u2010resistant epilepsy), which negatively impact neurodevelopment and quality of life. To capture the current state of the field, this review examines\n                    <jats:italic>KCNQx<\/jats:italic>\n                    and\n                    <jats:italic>KCNHx<\/jats:italic>\n                    expression patterns and electrical function in the brain and heart. In addition, it discusses several\n                    <jats:italic>KCNQx<\/jats:italic>\n                    and\n                    <jats:italic>KCNHx<\/jats:italic>\n                    variants that have been clinically and electrophysiologically characterized. Because these channel variants are associated with multi\u2010system pathologies, such as epileptogenesis, K\n                    <jats:sub>v<\/jats:sub>\n                    7 channel modulators provide a potential anti\u2010seizure therapy, particularly for people with intractable epilepsy. Ultimately an increased understanding of the role of K\n                    <jats:sub>v<\/jats:sub>\n                    channels throughout the body will fuel the development of innovative, safe, and effective therapies for people at a high risk of sudden death (SCD and SUDEP).\n                  <\/jats:p>","DOI":"10.1111\/epi.18066","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T09:55:42Z","timestamp":1722506142000},"page":"2537-2552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neurocardiac pathologies associated with potassium channelopathies"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3335-6384","authenticated-orcid":false,"given":"Veronica","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmacology SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-3847","authenticated-orcid":false,"given":"David S.","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Department of Pharmacology SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00301"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.10"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104130"},{"key":"e_1_2_13_5_1","first-page":"23","article-title":"The Kv10.1 channel: a promising target in cancer","volume":"30","author":"Luis E","year":"2022","journal-title":"Int J Mol Sci"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu335"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00348"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.10.010"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003056"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22644"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1840699"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06767.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013\u2010008\u20109032\u20105"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805651115"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00634.2006"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-08-04588.1994"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.02.012"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00814-X"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1048"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003309"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx184"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1999"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5591-09.2010"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26826"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.11.5120"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501770102"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.101.4.513"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.1.210"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.26"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.6.772"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.018333"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17455"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2013.02.009"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90275-I"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24263"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.154"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15199"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06733"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1533"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09071.2000"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-20-08111.1998"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.5.2476"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50799"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1212079"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.2208"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/384080a0"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7254"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002378200"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000289"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00031.2005"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4017"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.543306"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444316940"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.21.2314"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066843"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249440"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21106"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2008.07.002"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1733"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-338"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00648"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1890"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb14547.x"},{"key":"e_1_2_13_64_1","volume-title":"From neuron to brain","author":"John G","year":"2011"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216867110"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12353"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1375"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2023.06.016"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.154971"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000435296.72400.a1"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4423-14.2015"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo3625"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0980-23.2023"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80556-5"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2117640119"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003245200"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004644107"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3919-13.2014"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.05.016"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2116887119"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00509.2021"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81635-9"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306887110"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.20.5540"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0107"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711898"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050137"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201492"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2020-107511"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3282"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3153"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12201"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2307-13.2013"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12020132"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.313bn.x"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00104.2003"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7604285"},{"key":"e_1_2_13_98_1","article-title":"Expression of a mutant kcnj2 gene transcript in zebrafish ISRN","volume":"2013","author":"Leong IU","year":"2013","journal-title":"Mol Biol"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-24-09423.1997"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5434"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.570200"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90307-Y"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(57)90079-0"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.120295"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00891.2003"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.96.1.195"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000128561.28701.ea"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70117-5"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.890368"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335760.02995.ca"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.3109\/01677063.2012.674993"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12259"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.08.020"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.07.019"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.09.070"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08190.x"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.020990"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0709-4"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275970"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00179.2003"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04609.2001"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.675bg.x"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2020.1816107"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00832-4"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2610"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14596"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01249-1"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.58.3.591"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01629-5"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005320"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(95)00101-8"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11783-S"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00073-8"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2007.02.001"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1987.57.3.869"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90055-4"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(01)00193-0"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622311421542"},{"key":"e_1_2_13_139_1","unstructured":"HackethalV.Anticonvulsant potiga discontinued in June 2017. (2017 June 15). [cited 2024 Jul 8].https:\/\/www.neurologylive.com\/view\/anticonvulsant\u2010potiga\u2010discontinued\u2010june\u20102017"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00313"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.050"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02252"},{"key":"e_1_2_13_143_1","volume-title":"Charaterization of BHV\u20107000: a novel Kv7.2\/7.3 activator for the treatment of seizures","author":"Picchione K","year":"2023"},{"key":"e_1_2_13_144_1","unstructured":"DeanR LinS BankarG KhakhK MezeyovaJ LiJ et\u00a0al.Preclinical in\u00a0vitro and in\u00a0vivo comparison of the Kv7 activator XEN1101 with Ezogabine. In:Virtual Meeting: American Epilepsy Society.2020Nov 21."}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T06:54:59Z","timestamp":1731999299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":143,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/epi.18066"],"URL":"https:\/\/doi.org\/10.1111\/epi.18066","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}