{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T09:55:56Z","timestamp":1792317356741,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There are limited treatment options for individuals with drug\u2010resistant idiopathic generalized epilepsy (IGE). Small, limited case series suggest that centromedian thalamus deep brain stimulation (CM\u2010DBS) may be an effective treatment option. The optimal CM\u2010DBS target for IGE is underexamined. Here, we present a retrospective analysis of CM\u2010DBS targeting and efficacy for five patients with drug\u2010resistant IGE. Volume of tissue activated (VTA) overlap with CM nucleus was performed using an open\u2010source toolbox. Median follow\u2010up time was 13\u2009months. Median convulsive seizure frequency reduction was 66%. One patient had only absence seizures, with &gt;99% reduction in absence seizure frequency. Four patients had electrode contacts positioned within the CM nucleus target, all of whom had &gt;50% reduction in primary semiology seizure, with 85% median seizure reduction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.004, paired\u2010sample\n                    <jats:italic>t<\/jats:italic>\n                    test). Volumetric \u201csweet\u2010spot\u201d mapping revealed that best outcomes were correlated with stimulation of the middle ventral CM nucleus. Connectivity strength between the sweet\u2010spot region and central peri\u2010Rolandic cortex was increased significantly relative to other cortical regions (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20098.6\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    , Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    test). Our findings indicate that CM\u2010DBS can be an effective treatment for patients with IGE, highlight the importance of accurate targeting and targeting analysis, and within the context of prior work, suggest that ideal CM\u2010DBS targets may be syndrome specific.\n                  <\/jats:p>","DOI":"10.1111\/epi.18122","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T07:34:49Z","timestamp":1726299289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Centromedian thalamic deep brain stimulation for idiopathic generalized epilepsy: Connectivity and target optimization"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-265X","authenticated-orcid":false,"given":"Sihyeong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Permezel","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-6066","authenticated-orcid":false,"given":"Shruti","family":"Agashe","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamaleldin","family":"Osman","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics McGovern Medical School at UTHealth  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-1904","authenticated-orcid":false,"given":"Hugh D.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-6422","authenticated-orcid":false,"given":"Kai J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-7870","authenticated-orcid":false,"given":"Jamie J.","family":"Van Gompel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Starnes","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-5549","authenticated-orcid":false,"given":"Brian N.","family":"Lundstrom","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-0553","authenticated-orcid":false,"given":"Gregory A.","family":"Worrell","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-043X","authenticated-orcid":false,"given":"Nicholas M.","family":"Gregg","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109364"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12352"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2023.08.001"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.858413"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17467"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201003555\u20107"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.042"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.119862"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26368"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.09.069"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00171"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.05.015"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.056"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16895"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26280"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010211\u201033081\u20104_38"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102021\u2010327512"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T11:14:33Z","timestamp":1731928473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,14]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/epi.18122"],"URL":"https:\/\/doi.org\/10.1111\/epi.18122","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,14]]},"assertion":[{"value":"2024-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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