{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:30Z","timestamp":1787014170642,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3 NS123066"],"award-info":[{"award-number":["UG3 NS123066"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001605","name":"Epilepsy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Wearable nonelectroencephalographic biosignal recordings captured from the wrist offer enormous potential for seizure monitoring. However, signal quality remains a challenging factor affecting data reliability. Models trained for seizure detection depend on the quality of recordings in peri\u2010ictal periods in performing a feature\u2010based separation of ictal periods from interictal periods. Thus, this study aims to investigate the effect of epileptic seizures on signal quality, ensuring accurate and reliable monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study assesses the signal quality of wearable data during peri\u2010ictal phases of generalized tonic\u2013clonic and focal to bilateral tonic\u2013clonic seizures (TCS), focal motor seizures (FMS), and focal nonmotor seizures (FNMS). We evaluated accelerometer (ACC) activity and the signal quality of electrodermal activity (EDA) and blood volume pulse (BVP) data. Additionally, we analyzed the influence of peri\u2010ictal movements as assessed by ACC (ACC activity) on signal quality and examined intraictal subphases of focal to bilateral TCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 386 seizures from 111 individuals in three international epilepsy monitoring units. BVP signal quality and ACC activity levels differed between all seizure types. We found the largest decrease in BVP signal quality and increase in ACC activity when comparing the ictal phase to the pre\u2010 and postictal phases for TCS. Additionally, ACC activity was strongly negatively correlated with BVP signal quality for TCS and FMS, and weakly for FNMS. Intraictal analysis revealed that tonic and clonic subphases have the lowest BVP signal quality and the highest ACC activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Motor elements of seizures significantly impair BVP signal quality, but do not have significant effect on EDA signal quality, as assessed by wrist\u2010worn wearables. The results underscore the importance of signal quality assessment methods and careful selection of robust modalities to ensure reliable seizure detection. Future research is needed to explain whether seizure detection models' decisions are based on signal responses induced by physiological processes as opposed to artifacts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18138","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T06:41:11Z","timestamp":1728283271000},"page":"3513-3525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of epileptic seizures on the quality of biosignals recorded from wearables"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-8290","authenticated-orcid":false,"given":"Sebastian","family":"B\u00f6ttcher","sequence":"first","affiliation":[{"name":"Epilepsy Center University Medical Center\u2013University of Freiburg  Freiburg Germany"},{"name":"Department of Microsystems Engineering (IMTEK) University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-1863","authenticated-orcid":false,"given":"Nicolas","family":"Zabler","sequence":"additional","affiliation":[{"name":"Epilepsy Center University Medical Center\u2013University of Freiburg  Freiburg Germany"},{"name":"Department of Microsystems Engineering (IMTEK) University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-7333","authenticated-orcid":false,"given":"Michele","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Epilepsy and Clinical Neurophysiology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-1190","authenticated-orcid":false,"given":"Elisa","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology, and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1072-665X","authenticated-orcid":false,"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology, and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-8286","authenticated-orcid":false,"given":"Nino","family":"Epitashvili","sequence":"additional","affiliation":[{"name":"Epilepsy Center University Medical Center\u2013University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-8690","authenticated-orcid":false,"given":"Solveig","family":"Vieluf","sequence":"additional","affiliation":[{"name":"Division of Epilepsy and Clinical Neurophysiology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine I LMU University Hospital, LMU Munich  Munich Germany"},{"name":"German Center for Cardiovascular Research Partner Site Munich Heart Alliance  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1476-7777","authenticated-orcid":false,"given":"Matthias","family":"D\u00fcmpelmann","sequence":"additional","affiliation":[{"name":"Epilepsy Center University Medical Center\u2013University of Freiburg  Freiburg Germany"},{"name":"Department of Microsystems Engineering (IMTEK) University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-3140","authenticated-orcid":false,"given":"Mark P.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology, and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-8608","authenticated-orcid":false,"given":"Benjamin H.","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology and Physiology and Biomedical Engineering Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-0674","authenticated-orcid":false,"given":"Tobias","family":"Loddenkemper","sequence":"additional","affiliation":[{"name":"Division of Epilepsy and Clinical Neurophysiology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-0506","authenticated-orcid":false,"given":"Andreas","family":"Schulze\u2010Bonhage","sequence":"additional","affiliation":[{"name":"Epilepsy Center University Medical Center\u2013University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003509"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17307"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30038-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.06.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17678"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.06.023"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.713794"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.05.044"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117611"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2301913"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.12.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109486"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17774"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17297"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.06.029"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16521"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17202"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16990"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjno-2023-000442"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/s17102338"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006545"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/abef8a"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17517"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17654"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2023.06.002"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25949-x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13670"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21186017"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16527"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20020479"},{"key":"e_1_2_12_32_1","first-page":"797","article-title":"cvxEDA: a convex optimization approach to Electrodermal activity processing","volume":"63","author":"Greco A","year":"2016","journal-title":"IEEE Trans Biomed Eng"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2022.3174509"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2022.108864"},{"key":"e_1_2_12_35_1","first-page":"5593","volume-title":"37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","author":"Heldberg BE","year":"2015"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/s22093318"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16967"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2196\/27674"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.724904"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14053"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13634-020-00714-2"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2022.01.005"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.20196"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16590"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16621"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12618"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/s19143079"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13117"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.01.003"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16552"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17044"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:06:45Z","timestamp":1734322005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/epi.18138"],"URL":"https:\/\/doi.org\/10.1111\/epi.18138","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"2024-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}