{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:42:56Z","timestamp":1792010576584,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pathological amyloid\u2010\u03b2 (A\u03b2) accumulation and hyperphosphorylated tau proteins have been described in resected temporal lobe specimens of epilepsy patients. We aimed to determine cerebrospinal fluid (CSF) A\u03b21\u201042 and p181\u2010tau levels and cerebral A\u03b2 deposits on positron emission tomography (A\u03b2 PET) and correlate these findings with cognitive performance in adults with drug\u2010resistant temporal lobe epilepsy (TLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, we enrolled individuals with drug\u2010resistant TLE who were 25\u201355\u2009years old. Each participant underwent <jats:sup>18<\/jats:sup>F\u2010flutemetamol PET, determination of CSF A\u03b21\u201042, p181\u2010tau, and total tau, and a comprehensive neuropsychological assessment. We evaluated normalized standard uptake value ratios (SUVRs) for different brain regions on A\u03b2 PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients (mean age\u2009=\u200941.9\u2009\u00b1\u2009SD 8.1\u2009years, 57% men) were included. The median disease duration was 9.5 (interquartile range\u2009=\u20094\u201324) years. Twenty\u2010six patients (87%) had a clinically significant cognitive impairment on neuropsychological evaluation, 18 (69%) of the amnesic type. On A\u03b2 PET, high uptake was observed in both mesial temporal regions (ipsilateral: SUVR <jats:italic>z<\/jats:italic>\u2010score = .90, 95% confidence interval [CI] = .60\u20131.20; contralateral: SUVR <jats:italic>z<\/jats:italic>\u2010score = .92, 95% CI = .57\u20131.27; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), which was higher when compared to SUVR <jats:italic>z<\/jats:italic>\u2010scores in all the remaining regions (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and in the ipsilateral anterior cingulate (SUVR <jats:italic>z<\/jats:italic>\u2010score = .27, 95% CI = .04\u2013.49, <jats:italic>p<\/jats:italic>\u2009=\u2009.020). No significant deposition was observed in other regions. Seven patients (23%) had low A\u03b21\u201042 levels, and two (7%) had elevated p181\u2010tau levels in CSF. Higher p181\u2010tau levels correlated with poorer verbal fluency (<jats:italic>R<\/jats:italic>\u2009=\u2009\u2212.427, <jats:italic>p<\/jats:italic>\u2009=\u2009.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our findings reveal a considerable A\u03b2 deposition in mesial temporal regions and ipsilateral anterior cingulate among adults with drug\u2010resistant TLE. Additionally, abnormal CSF A\u03b21\u201042 levels were observed in a significant proportion of patients, and p181\u2010tau levels were associated with verbal fluency. These results suggest that markers of neuronal damage can be observed in adults with TLE, warranting further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18142","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T10:35:07Z","timestamp":1728988507000},"page":"3664-3675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Amyloid deposition in adults with drug\u2010resistant temporal lobe epilepsy"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-1237","authenticated-orcid":false,"given":"Elena","family":"Fonseca","sequence":"first","affiliation":[{"name":"Epilepsy Unit, Neurology Department, Medicine Department Universitat Aut\u00f2noma de Barcelona, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Research Group on Status Epilepticus and Acute Seizures, Vall d'Hebron Research 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