{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:09:26Z","timestamp":1791331766796,"version":"4.3.1"},"reference-count":123,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/T04294X\/1"],"award-info":[{"award-number":["MR\/T04294X\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/V026569\/1"],"award-info":[{"award-number":["MR\/V026569\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vagus nerve stimulation (VNS) is an established therapy for drug\u2010resistant epilepsy. However, there is a lack of reliable predictors of VNS response in clinical use. The identification of factors predictive of VNS response is important for patient selection and stratification as well as tailored stimulation programming. We conducted a narrative review of the existing literature on prognostic markers for VNS response using clinical, demographic, biochemical, and modality\u2010specific information such as from electroencephalography (EEG), magnetoencephalography, and magnetic resonance imaging (MRI). No individual marker demonstrated sufficient predictive power for individual patients, although several have been suggested, with some promising initial findings. Combining markers from underresearched modalities such as T1\u2010weighted MRI morphometrics and EEG may provide better strategies for treatment optimization.<\/jats:p>","DOI":"10.1111\/epi.18153","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T09:10:25Z","timestamp":1729069825000},"page":"3441-3456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Vagus nerve stimulation for epilepsy: A narrative review of factors predictive of response"],"prefix":"10.1111","volume":"65","author":[{"given":"Harry J.","family":"Clifford","sequence":"first","affiliation":[{"name":"Computational Neurology Neurosicence and Psychiatry Lab, School of Computing Newcastle University  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menaka P.","family":"Paranathala","sequence":"additional","affiliation":[{"name":"Neurosciences Royal Victoria Infirmary  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-6273","authenticated-orcid":false,"given":"Yujiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Computational Neurology Neurosicence and Psychiatry Lab, School of Computing Newcastle University  Newcastle Upon Tyne UK"},{"name":"Faculty of Medical Sciences Newcastle University  Newcastle Upon Tyne UK"},{"name":"UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-8623","authenticated-orcid":false,"given":"Rhys H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Neurosciences Royal Victoria Infirmary  Newcastle Upon Tyne UK"},{"name":"Faculty of Medical Sciences Newcastle University  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"da Silva Costa","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Newcastle University  Newcastle Upon Tyne UK"},{"name":"Northern Centre for Mood Disorders, Newcastle University, Cumbria, Northumberland Tyne and Wear NHS Foundation Trust  Newcastle Upon Tyne UK"},{"name":"National Institute for Health and Care Research, Newcastle Biomedical Research Centre  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Duncan","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-9838","authenticated-orcid":false,"given":"Peter N.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Computational Neurology Neurosicence and Psychiatry Lab, School of Computing Newcastle University  Newcastle Upon Tyne UK"},{"name":"Faculty of Medical Sciences Newcastle University  Newcastle Upon Tyne UK"},{"name":"UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02397.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.10.027"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2011.07.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.10.017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.09.027"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.10.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(00)00181-9"},{"key":"e_1_2_10_9_1","unstructured":"NICE.NICE guideline NG217.https:\/\/www.nice.org.uk\/guidance\/ng2172022."},{"key":"e_1_2_10_10_1","unstructured":"NICE.Epilepsies in children young people and adults: Diagnosis and management [14] evidence review: vagus nerve stimulation.https:\/\/www.nice.org.uk\/guidance\/ng217\/evidence\/14\u2010vagus\u2010nerve\u2010stimulation\u2010pdf\u20103983662827772022."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(95)00245-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab380"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv130"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad292"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22722"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02079.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-328185"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104848"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03191.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.JNS131422"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.031781"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810051"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040733"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(95)00027-U"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90217-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.6.FOCUS18216"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/13813459109145916"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13209"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0272-3"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14270"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902930404"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315530"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00170-3"},{"issue":"7","key":"e_1_2_10_35_1","first-page":"96","article-title":"Vagus nerve stimulation as a treatment for seizures associated with hypothalamic hamartomas","volume":"41","author":"Frost MD","year":"2000","journal-title":"Epilepsia"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065716500489"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.09.015"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.03.018"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.12.044"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13923"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.06.017"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2020.0798"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1030118"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2020.106463"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1074997"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.037085"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00392"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.635787"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2023.09.005"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.6.JNS18735"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.02.171"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2011.04.002"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.03.020"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102205"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813510970"},{"issue":"4","key":"e_1_2_10_56_1","first-page":"60","article-title":"Research article vagus nerve stimulation in adults with drug\u2010resistant epilepsy: Efficacy, adverse effects and outcomes","volume":"34","author":"Hava Ozlem D","year":"2017","journal-title":"J Neurol Sci [Turkish]."},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.03.002"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109107"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14021"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25574"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046791"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa200"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu039"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.07.023"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.09.014"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073820974855"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.02.010"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2020.106432"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2003.09.009"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.02.055"},{"issue":"5","key":"e_1_2_10_71_1","first-page":"10","article-title":"Pediatric vagus nerve stimulation: Case series outcomes and future directions","volume":"92","author":"LoPresti MA","year":"2022","journal-title":"Neurosurgery"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3182230ae3"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2005.09.006"},{"issue":"2","key":"e_1_2_10_74_1","first-page":"506","article-title":"Vagus nerve stimulation therapy after failed cranial surgery for intractable epilepsy: Results from the vagus nerve stimulation therapy patient outcome registry","volume":"62","author":"Amar AP","year":"2008","journal-title":"Neurosurgery"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv015"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2136"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21669-3"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.03.035"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2021.02.017"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.691328"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-022-05653-x"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341402"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.06.001"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2022.05.016"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0432-8"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15633"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001165"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2020.04.003"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2022.108861"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12376"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107728"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.02.012"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000288"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12288"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15681"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.02.015"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2021.05.017"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.709436"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2021.02.015"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01940.x"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.06.032"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2017.0929"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12611"},{"issue":"1","key":"e_1_2_10_104_1","article-title":"Comorbidity of epilepsy and depression: Associated pathophysiology and management","volume":"14","author":"Alhashimi R","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_105_1","unstructured":"NICE.Implanted vagus nerve stimulation for treatment\u2010resistant depression.https:\/\/www.nice.org.uk\/guidance\/ipg6792020."},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.01659"},{"key":"e_1_2_10_107_1","first-page":"382","article-title":"Management of epilepsy during pregnancy and lactation","author":"Hope OA","year":"2023","journal-title":"BMJ"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70075-9"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02299.x"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjno-2021-000218"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-055886"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.839163"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.10.054"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.002"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2014.08.010"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00008-X"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww299"},{"key":"e_1_2_10_118_1","first-page":"4884","article-title":"An in silico approach for pre\u2010surgical evaluation of an epileptic cortex","volume":"2014","author":"Sinha N","year":"2014","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.04.049"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17690"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00202"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.012"},{"key":"e_1_2_10_123_1","first-page":"arXiv","volume-title":"Vagus nerve stimulation: laying the groundwork for predictive network\u2010based computer models","author":"Ingham J","year":"2024"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.3880"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:06:22Z","timestamp":1734321982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":123,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/epi.18153"],"URL":"https:\/\/doi.org\/10.1111\/epi.18153","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,16]]},"assertion":[{"value":"2024-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}