{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T07:35:49Z","timestamp":1784446549962,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011476","name":"European Paediatric Neurology Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Few studies have evaluated the efficacy of antiseizure medications (ASMs) according to the etiology of neonatal acute provoked seizures. We aimed to investigate the response to ASMs in term\/near term neonates with acute arterial ischemic stroke (AIS), as well as the type of seizure at presentation and the monitoring approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated neonates from 15 European level IV neonatal intensive care units who presented with seizures due to AIS and were monitored by continuous electroencephalography (cEEG) and\/or amplitude\u2010integrated EEG (aEEG) in whom actual recordings, timing, doses, and response to ASMs were available for review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seven neonates were referred, and 88 were included. Of those, 56 met the criteria for evaluating the treatment response. The mean time to treatment was 7.9 h (SD\u2009=\u200916.4), and the most frequently administered first\u2010line ASM was phenobarbital (PB; 74\/88, 84.1%). Seizures were controlled within 24\u2009h from onset of symptoms in 64.3% (36\/56) of neonates. Phenytoin (PHT) was effective in almost all neonates in whom it was trialed (24\/25, 96.0%), whereas PB was effective in only 22.0% of patients (11\/50). Infants treated with PB or PHT as first\u2010line treatment (53\/56, 94.6%) showed a higher response rate with PHT (6\/6, 100.0%) than with PB (11\/47, 23.4%). Monitoring approach and seizure types were evaluated in 88 infants. Forty\u2010six of 88 (52.3%) were monitored with cEEG and 47.7% (42\/88) with aEEG, with or without intermittent cEEG. The mean monitoring duration was 65.8\u2009h (SD\u2009=\u200939.21). In 83 of 88 (94.3%) infants, the type of seizure suspected clinically prior to monitoring was confirmed afterward. Unilateral focal clonic seizures were seen in 71 of 88 infants (80.7%), whereas 11 of 88 (12.5%) presented with ictal apneas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our findings provide evidence in a large, homogenous cohort that PHT is more effective than PB in treating neonatal acute symptomatic seizures due to AIS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18194","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T11:58:49Z","timestamp":1732363129000},"page":"394-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness of sodium channel blockers in treating neonatal seizures due to arterial ischemic stroke"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-7561","authenticated-orcid":false,"given":"Veronica","family":"Pegoraro","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology Saint\u2010Luc University Hospital, Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Viellevoye","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatal Intensive Care Unit Centre Hospitalier Universitaire\u2010Centre Hospitalier R\u00e9gional (CHU\u2010CHR) Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Malfilatre","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit CHU Tivoli  La Louvi\u00e8re Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robertino","family":"Dilena","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-4724","authenticated-orcid":false,"given":"Jacopo","family":"Proietti","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health Azienda Ospedaliera Universitaria Integrata (AOUI) Verona  Verona Italy"},{"name":"Department of Engineering for Innovation Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Mauro","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health Friuli Centrale Health University Authority  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Zardini","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Division of Pediatric Neurology and Neurophysiology University of Padua  Padua 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Scientifico (IRCCS) Istituto Delle Scienze Neurologiche di Bologna Unit\u00e0 Operativa Complessa (UOC) Neuropsichiatria dell'et\u00e0 Pediatrica  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Campi","sequence":"additional","affiliation":[{"name":"Clinical and Academic Area Fetal\u2013Neonatal and Cardiological Sciences, Neonatal Intensive Care Unit, Bambino Ges\u00f9 Children's Hospital Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Reis","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico Neonatal Intensive Care Unit  Milan Italy"},{"name":"University of Milan Department of Clinical Sciences and Community Health  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Nguyen The Tich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Centre Hospitalier R\u00e9gional Universitaire (CHRU) Lille University Hospital  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Felderhoff\u2010M\u00fcser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, Neonatal Intensive Care Unit University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health Friuli Centrale Health University Authority  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-6848","authenticated-orcid":false,"given":"Stefano","family":"Sartori","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Division of Pediatric Neurology and Neurophysiology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Benders","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Medical Center, Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Pittini","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health Friuli Centrale Health University Authority  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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