{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:06:14Z","timestamp":1784869574811,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>General anesthesia (GA) earlier than recommended (as first\u2010 or second\u2010line treatment) was recently described to improve status epilepticus (SE) outcome. We aimed to assess the impact of early GA on outcome in matched groups. Data from a multicenter, prospective cohort of 1179 SE episodes in 1049 adults were retrospectively analyzed. Incident SE episodes were categorized as \u201cearly anesthesia\u201d (eGA; GA as first\u2010 or second\u2010line treatment) or \u201cnon\u2010early anesthesia\u201d (neGA; GA after second\u2010line treatment or not at all). Using propensity score matching, eGA episodes were paired 1:4 with neGA episodes. We assessed survival, functional outcomes at discharge (good: modified Rankin Scale\u2009=\u20090\u20132 or no worsening), SE cessation rate, SE duration, and hospital stay. Among 1049 SE episodes, 55 (5.2%) received eGA, and 994 constituted the neGA group; 220 represented the matched controls. Patients receiving eGA were younger (median\u2009=\u200963, interquartile range [IQR] =\u200956\u201376 vs. median\u2009=\u200970, IQR\u2009=\u200954\u201380\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u2009.004), had deeper consciousness impairment (80% vs. 40% stuporous\/comatose, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and had more severe SE forms (89% vs. 54% generalized convulsive SE\/nonconvulsive SE in coma, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Mortality, functional outcome, SE cessation rate, and duration of SE and hospital stay were similar between the eGA group and matched controls. We conclude that early anesthesia for SE treatment did not influence prognosis.<\/jats:p>","DOI":"10.1111\/epi.18203","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T15:58:12Z","timestamp":1732809492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of early general anesthesia with outcome in adults with status epilepticus: A propensity\u2010matched observational study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9300-4443","authenticated-orcid":false,"given":"Isabelle","family":"Beuchat","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire Vaudois University of Lausanne  \u00c9cublens Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-7083","authenticated-orcid":false,"given":"Jan","family":"Novy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire Vaudois University of Lausanne  \u00c9cublens Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-4577","authenticated-orcid":false,"given":"Vincent","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire Vaudois University of Lausanne  \u00c9cublens Switzerland"},{"name":"Neurology Department Neurocentre, H\u00f4pital du Valais  Sion Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Rosenow","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe University and University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Loewe Center for Personalized Translational Epilepsy Research Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kellinghaus","sequence":"additional","affiliation":[{"name":"Department of Neurology Klinikum Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Epilepsy Center, M\u00fcnster\u2010Osnabr\u00fcck, Campus Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"R\u00fcegg","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Tilz","sequence":"additional","affiliation":[{"name":"Neurology and Epilepsy Center  Ravensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care, and Neurorehabilitation Christian Doppler University Hospital, Paracelsus Medical University, Center for Cognitive Neuroscience, member of the European Reference Network EpiCARE  Salzburg Austria"},{"name":"Neuroscience Institute, Christian Doppler University Hospital, Paracelsus Medical University, Center for Cognitive Neuroscience  Salzburg Austria"},{"name":"Department of Public Health, Health Services Research, and Health Technology Assessment University for Health Sciences, Medical Informatics, and Technology  Hall in Tirol Austria"},{"name":"Karl Landsteiner Institute for Neurorehabilitation and Space Neurology  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Unterberger","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeljko","family":"Uzelac","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-9915","authenticated-orcid":false,"given":"Adam","family":"Strzelczyk","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe University and University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Loewe Center for Personalized Translational Epilepsy Research Goethe University Frankfurt  Frankfurt am Main Germany"},{"name":"Epilepsy Center Hessen and Department of Neurology Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-172X","authenticated-orcid":false,"given":"Andrea O.","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire Vaudois University of Lausanne  \u00c9cublens Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-012-9695-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000009"},{"issue":"99","key":"e_1_2_8_5_1","first-page":"e1824","article-title":"Refractory status epilepticus: risk factors and analysis of intubation in the multicenter SENSE registry","volume":"18","author":"Beuchat 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