{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:46:25Z","timestamp":1788543985664,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP#566544"],"award-info":[{"award-number":["APP#566544"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["130100100"],"award-info":[{"award-number":["130100100"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The 5xFAD mouse model of Alzheimer disease (AD) recapitulates amyloid\u2010beta (A\u03b2) deposition and pronounced seizure susceptibility observed in patients with AD. Forty\u2010hertz audiovisual stimulation is a noninvasive technique that entrains gamma neural oscillations and can reduce A\u03b2 pathology and modulate glial expression in AD models. We hypothesized that 40\u2010Hz sensory stimulation would improve seizure susceptibility in 5xFAD mice and this would be associated with reduction of plaques and modulation of glial phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      5xFAD mice and wild\u2010type (WT) littermates received 1\u2009h\/day 40\u2010Hz audiovisual stimulation or sham (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097\u201311\/group), beginning 2\u2009weeks before and continuing throughout amygdala kindling epileptogenesis. Postmortem analyses included A\u03b2 pathology and morphology of astrocytes and microglia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      5xFAD mice exhibited enhanced susceptibility to seizures compared to WT, evidenced by fewer stimulations to reach kindling endpoint (incidence rate ratio [IRR]\u2009=\u20091.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001) and a trend to higher seizure severity (odds ratio [OR]\u2009=\u2009.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.059). Forty\u2010hertz stimulation reduced the behavioral severity of the first seizure (OR\u2009=\u20094.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02) and delayed epileptogenesis, increasing the number of stimulations required to reach kindling endpoint (IRR\u2009=\u2009.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01) compared to sham, regardless of genotype. 5xFAD mice receiving sensory stimulation exhibited ~50% reduction in amyloid pathology compared to sham. Furthermore, markers of astrocytes and microglia were upregulated in both genotypes receiving 40\u2010Hz stimulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Forty\u2010hertz sensory entrainment slows epileptogenesis in the mouse amygdala kindling model. Although this intervention improves A\u03b2 pathology in 5xFAD mice, the observed antiepileptogenic effect may also relate to effects on glia, because mice without A\u03b2 plaques (i.e., WT) also experienced antiepileptogenic effects of the intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18222","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:35:31Z","timestamp":1735612531000},"page":"886-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Forty\u2010hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7322-1864","authenticated-orcid":false,"given":"Jennifer","family":"Tinston","sequence":"first","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6165-5639","authenticated-orcid":false,"given":"Anna","family":"Harutyunyan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine Royal Melbourne Hospital, University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1888-6917","authenticated-orcid":false,"given":"Zhibin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-8439","authenticated-orcid":false,"given":"Nigel C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine Royal Melbourne Hospital, University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Neurology Alfred Hospital  Melbourne Victoria 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