{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:59:54Z","timestamp":1787677194220,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periventricular nodular heterotopia (PVNH) is a neuronal migration disorder often associated with drug\u2010resistant epilepsy. The epileptogenic zone network (EZN) in PVNH is generally large, contraindicating surgery. Stereoelectroencephalography (SEEG) can be proposed to map the EZN and perform radiofrequency thermocoagulation (THC) with an efficacy rate of approximately 65%. There are genetic forms of PVNH, particularly with mutations in the filamin A gene (<jats:italic>FLNA<\/jats:italic>). However, data on SEEG\u2010guided THC in these patients still have not been described. We report four patients with <jats:italic>FLNA<\/jats:italic>\u2010positive PVNH who underwent SEEG\u2010guided THC. All were women with several types of seizures and psychiatric comorbidities. EZN was extensive and often bilateral, including a part of the heterotopias. The outcomes of SEEG\u2010guided THC varied; two patients experienced significant seizure reduction and improvement in psychiatric symptoms (Engel class I\u2013II), one showed partial improvement (Engel class III), and one had no significant benefit (Engel class IV). Psychiatric comorbidities, including posttraumatic stress disorder, depression, and anxiety, were present in all cases, with some patients showing symptom improvement alongside seizure reduction. Despite genetic origin, SEEG\u2010guided THC can be proposed in <jats:italic>FLNA<\/jats:italic>\u2010positive PVNH\u2010related epilepsy, although outcomes vary. The presence of <jats:italic>FLNA<\/jats:italic> mutations should not contraindicate surgical intervention but may influence the therapeutic response. Further research is needed to understand the impact of genetic variants on epilepsy outcome.<\/jats:p>","DOI":"10.1111\/epi.18231","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T13:59:52Z","timestamp":1734357592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>Stereoelectroencephalographic<\/scp> thermocoagulation in <scp><i>FLNA<\/i><\/scp>\u2010positive heterotopia: Is it an effective treatment?"],"prefix":"10.1111","volume":"66","author":[{"given":"Lucie","family":"De Clerck","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst,  Marseille France"},{"name":"APHM, Assistance Publique des Hopitaux de Marseille, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Pelliccia","sequence":"additional","affiliation":[{"name":"Epilepsy Surgery Center C. Munari, Niguarda Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Carron","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst,  Marseille France"},{"name":"APHM, Assistance Publique des Hopitaux de Marseille, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Tr\u00e9buchon","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst,  Marseille France"},{"name":"APHM, Assistance Publique des Hopitaux de Marseille, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tassi","sequence":"additional","affiliation":[{"name":"Epilepsy Surgery Center C. Munari, Niguarda Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-0297","authenticated-orcid":false,"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst,  Marseille France"},{"name":"APHM, Assistance Publique des Hopitaux de Marseille, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pizzo","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst,  Marseille France"},{"name":"APHM, Assistance Publique des Hopitaux de Marseille, Timone Hospital, Epileptology and Cerebral Rhythmology  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl125"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00374.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.03.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt249"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16328"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.162263"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132818.84827.4D"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh357"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01717.x"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"Stereo\u2010EEG\u2010based ictal functional connectivity in patients with periventricular nodular heterotopia\u2010related epilepsy","volume":"2024","author":"Zanello M","year":"2023","journal-title":"Epilepsia"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13895"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13919"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.09.118"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17168"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.07.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.10.022"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.20023"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010021\u201003064\u20101"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.20177"},{"key":"e_1_2_7_21_1","first-page":"1010","article-title":"Grey matter heterotopia subtypes show specific morpho\u2010electric signatures and network dynamics","volume":"147","author":"Vermoyal J","year":"2023","journal-title":"Brain"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn111"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T16:35:54Z","timestamp":1739550954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/epi.18231"],"URL":"https:\/\/doi.org\/10.1111\/epi.18231","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"2024-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}