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This seizure onset pattern, referred to as\n                    <jats:italic>chirp,<\/jats:italic>\n                    has been identified as a highly specific and sensitive marker of focal seizures that are characterized by low\u2010voltage fast activity. We report that this chirp pattern is also observed in animal models of temporal lobe epilepsy in both in\u00a0vivo and in\u00a0vitro preparations. We propose here that chirps mirror the involvement of synchronous interneuron firing that is known to represent a specific cellular mechanism leading to the initiation of focal seizures, in particular those characterized by low\u2010voltage fast activity.\n                  <\/jats:p>","DOI":"10.1111\/epi.18245","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T09:05:05Z","timestamp":1735203905000},"page":"621-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fast activity\n                    <i>chirp<\/i>\n                    patterns in focal seizures from patients and animal models"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-7037","authenticated-orcid":false,"given":"Maxime","family":"L\u00e9vesque","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery Montreal Neurological 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