{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:43:00Z","timestamp":1791657780014,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether local lesions created by stereo\u2010electroencephalography (SEEG)\u2013guided radiofrequency thermocoagulation (RFTC) affect distant brain connectivity and excitability in patients with focal, drug\u2010resistant epilepsy (DRE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients with focal DRE underwent SEEG implantation and subsequently 1\u2009Hz bipolar repetitive electrical stimulation (RES) for 30\u2009s before and after RFTC. Root mean square (RMS) of cortico\u2010cortical evoked potentials (CCEPs) was calculated for 15\u2009ms to 300\u2009ms post\u2010stimulation with baseline correction. Contact pairs were categorized as both coagulated, hybrid, or both non\u2010coagulated. The data were divided into nine categories based on the stimulating and recording contact pair combinations. RMS of CCEPs was compared before and after (&lt;12\u2009h) RFTC using a two\u2010sample <jats:italic>t<\/jats:italic> test (Hochberg corrected, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) for each patient. Boost score, indicating power increase during seizures before RFTC relative to baseline, was analyzed in 4 s windows with 1 s overlap during seizure duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RFTC altered connectivity across all categories. Of interest, decreases and increases in RMS were observed in connections between non\u2010coagulated contacts distant from coagulation site (range: 1.09\u201385\u2009mm, median\u2009=\u200917.7\u2009mm, interquartile range [IQR] 10.1\u201332.3). Contact pairs involved in significantly altered non\u2010coagulated connections showed a higher boost score correlation in the theta, beta, and gamma bands, as well as a stronger maximum correlation with coagulated sites in the delta band than contacts for which connectivity did not change after RFTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study highlights how local lesions alter distant brain connectivity, providing insights for future research on epilepsy network changes and seizure outcomes following RFTC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18270","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T14:48:24Z","timestamp":1737384504000},"page":"1260-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impact of radiofrequency thermocoagulation on brain connectivity in drug\u2010resistant epilepsy: Insights from stereo\u2010electroencephalography and cortico\u2010cortical evoked potentials"],"prefix":"10.1111","volume":"66","author":[{"given":"Justyna","family":"Gula","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Mental Health and Neuroscience (MHeNS) Research Institute, University Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-428X","authenticated-orcid":false,"given":"Rutger J.","family":"Slegers","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Department of Neurosurgery Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raf H. M.","family":"Van Hoof","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-3359","authenticated-orcid":false,"given":"Balu","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mischi","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering University of Eindhoven  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne H. J. M.","family":"van Kranen\u2010Mastenbroek","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Mental Health and Neuroscience (MHeNS) Research Institute, University Maastricht  Maastricht The Netherlands"},{"name":"Department of Electrical Engineering University of Eindhoven  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse E. C. W.","family":"Van Straaten","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Mental Health and Neuroscience (MHeNS) Research Institute, University Maastricht  Maastricht The Netherlands"},{"name":"Department of Neurosurgery Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Electrical Engineering University of Eindhoven  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Hilkman","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Department of Clinical Neurophysiology Maastricht University Medical Centre (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Wagner","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Department of Neurosurgery Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Colon","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Centre Des Etudes et Traitement de l'Epilepsie (CETE) Centre Hospitalier Universitaire Martinique  Fort\u2010de\u2010France France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf E. M. G.","family":"Schijns","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology (ACE), Kempenhaeghe\/Maastricht UMC+, Maastricht &amp; Heeze  Maastricht The Netherlands"},{"name":"Mental Health and Neuroscience (MHeNS) Research Institute, University Maastricht  Maastricht The Netherlands"},{"name":"Department of Neurosurgery Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borb\u00e1la","family":"Hunyadi","sequence":"additional","affiliation":[{"name":"Signal Processing Systems Section, Department of Microelectronics Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-8060","authenticated-orcid":false,"given":"Jacobus F. 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