{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:59:30Z","timestamp":1775141970887,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["No. 3\/2\/July\u20102019\/PG\u2010Thesis\u2010HRD (15)"],"award-info":[{"award-number":["No. 3\/2\/July\u20102019\/PG\u2010Thesis\u2010HRD (15)"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The ketogenic diet has been the mainstay of treatment of drug\u2010resistant epilepsy (DRE). No comparative trials have been conducted to assess the efficacy of the two less strict ketogenic diets: modified Atkins diet (MAD) and low glycemic index treatment (LGIT). This study assesses the non\u2010inferiority of LGIT compared with MAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an open\u2010label randomized non\u2010inferiority trial. Children with DRE were randomized to receive either MAD or LGIT as an add\u2010on to anti\u2010seizure medications. The primary endpoint was percentage seizure reduction at the end of 24\u2009weeks of therapy compared to the baseline. The non\u2010inferiority margin of \u221215% was predefined to calculate the sample size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010one children were enrolled and randomized to receive either MAD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945) or LGIT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946). Intention\u2010to\u2010treat analysis done at the end of 24\u2009weeks of therapy showed a mean (\u00b1standard deviation [SD]) percentage seizure reduction of 60.7% (\u00b141.3) in the MAD sub\u2010group and 57% (\u00b139.4) in the LGIT sub\u2010group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.664). The absolute difference between the means of percentage seizure reduction was \u22123.7 (\u221220.5 to 13.2) and crossed the non\u2010inferiority margin. Ten children in the MAD group and nine children in the LGIT group did not complete 24\u2009weeks of therapy. Adverse effects were comparable between the arms (MAD, 66.6%; LGIT, 50%), although serious adverse effects were higher in the MAD arm. The most common adverse effect was decreased acceptance (24.2%) followed by decreased satiety (9.9%), vomiting (9.9%), weight loss (5.5%), constipation (5.5%), and diarrhea (3.3%). Dyslipidemia was more commonly seen in the MAD group (MAD, six; LGIT, one). One death in the LGIT arm was unrelated to therapy. Although there was no statistically significant difference in improvement in cognition, behavior, and quality of life scales, improvement was noted from baseline scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>LGIT may be non\u2010inferior to MAD in the treatment of children with DRE with the advantage of increased acceptance and fewer adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18292","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T08:14:11Z","timestamp":1738224851000},"page":"1550-1559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of efficacy of low glycemic index treatment and modified Atkins diet among children with drug\u2010resistant epilepsy: A randomized non\u2010inferiority trial"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-5899","authenticated-orcid":false,"given":"Vaishakh","family":"Anand","sequence":"first","affiliation":[{"name":"Centre of Excellence &amp; 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Advanced Research for Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-0441","authenticated-orcid":false,"given":"Aakash","family":"Mahesan","sequence":"additional","affiliation":[{"name":"Centre of Excellence &amp; Advanced Research for Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2367-6591","authenticated-orcid":false,"given":"Vishal","family":"Sondhi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Armed Forces Medical College  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanak L.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Senior Dietician All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-7386","authenticated-orcid":false,"given":"Biswaroop","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Centre of Excellence &amp; 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