{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:59:36Z","timestamp":1776153576396,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS106611"],"award-info":[{"award-number":["R01 NS106611"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS112816\u201001"],"award-info":[{"award-number":["R01 NS112816\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 NS113198"],"award-info":[{"award-number":["U01 NS113198"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Subjects with left temporal lobe epilepsy may either show altered hemispheric language lateralization or retain typical, left lateralization. Examining the integrity of white matter pathways involved in the adaptation or maintenance of language lateralization in these patients could have important clinical implications for preserving or potentiating compensatory language mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We combined task functional magnetic resonance imaging and structural diffusion metrics to determine the dependency of lobe\u2010based language laterality on white matter integrity in healthy participants and left temporal lobe epilepsy (TLE) patients. We tested for differences between individuals who expressed typical, left hemisphere laterality compared to those with atypical laterality patterns (bilateral or right hemisphere biased).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 41 left TLE patients and 51 sex\u2010 and age\u2010matched healthy participants (HPs) were enrolled. In left temporal lobe epilepsy, typical patterns of frontal and temporal lateralities were less conditioned by the language\u2010related white matter connections of the left temporal lobe. In typically organized epilepsy subjects, temporal lobe language laterality was dependent upon the structural connectivities of the left parietal lobe. Among atypically organized individuals, compared to HPs, TLE patients displayed frontal and parietal language lateralities mediated by the structural connectivities of the left parietal lobe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Language\u2010related left parietal lobe connections were critical both for maintaining typical left hemisphere\u2010biased language processing in the temporal lobe and for the formation of noncanonical, potentially adaptive language processing asymmetries in the frontal and parietal lobes. Assessments of the laterality and integrity of language skills in left temporal lobe epilepsy will require modeling white matter structural influences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18298","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:50:45Z","timestamp":1741755045000},"page":"1599-1612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Left parietal structural connectivity mediates typical and atypical language laterality in temporal lobe epilepsy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-6501","authenticated-orcid":false,"given":"Salvatore","family":"Citro","sequence":"first","affiliation":[{"name":"IRCCS SYNLAB SDN  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam S.","family":"Javidi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Farber Institute for Neuroscience Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ankeeta Ankeeta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Farber Institute for Neuroscience Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-2918","authenticated-orcid":false,"given":"Xiaosong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Farber Institute for Neuroscience Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Kry","sequence":"additional","affiliation":[{"name":"Department of Neurology, Farber Institute for Neuroscience Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0708-6006","authenticated-orcid":false,"given":"Michael R.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Farber Institute for Neuroscience Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-3290","authenticated-orcid":false,"given":"Joseph I.","family":"Tracy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Farber Institute for Neuroscience Thomas Jefferson University  Philadelphia Pennsylvania 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