{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:00:22Z","timestamp":1775142022247,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recent studies highlight the amygdala's crucial role in temporal lobe epilepsy (TLE), particularly in magnetic resonance imaging\u2010negative cases and new TLE subtypes with structural amygdala changes. This study aims to investigate the electrophysiological properties and connectivity patterns of the amygdaloid complex in TLE patients using stereoelectroencephalography (SEEG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From March 2020 to December 2023, we collected data from nine patients with drug\u2010resistant TLE who underwent SEEG with dual amygdala trajectories: dorsal amygdala (DA) targeting medial and central nuclei, and ventral amygdala (VA) targeting basal and lateral nuclei. We analyzed interictal and ictal activities, focusing on power spectral density, interictal epileptiform discharges (IEDs), and coherence between DA and VA regions and ipsilateral regions of the temporal\u2013limbic network, including the hippocampus, superior temporal gyrus, entorhinal cortex, fusiform gyrus, orbitofrontal cortex, temporal pole, and ventral insula.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IEDs were significantly higher in the DA, particularly in patients with epileptogenic zones involving the amygdala. We identified frequency\u2010dependent connectivity patterns between DA and VA with ipsilateral cortical areas of interest during ictal activity. The VA exhibited higher connectivity with the limbic network in a greater number of seizures, particularly with the hippocampal head, entorhinal cortex, fusiform gyrus, and temporal pole in delta and theta frequencies. In contrast, DA connectivity was mainly confined to the hippocampus in theta and high\u2010gamma frequency ranges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our findings reveal distinct functional connectivity patterns and potentially divergent roles of DA and VA in TLE. These insights could refine intracranial sampling protocols of the amygdaloid complex, guiding more precise strategies for resection and neuromodulation in TLE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18317","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T04:06:16Z","timestamp":1739851576000},"page":"1945-1958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential functional connectivity of amygdala in drug\u2010resistant temporal lobe epilepsy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-9642","authenticated-orcid":false,"given":"Thandar","family":"Aung","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilly W.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Neurosurgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Neurosurgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke C.","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-3785","authenticated-orcid":false,"given":"Naoki","family":"Ikegaya","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Neurosurgery Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Modo","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Center for the Neural Basis of Cognition University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Gonzalez Martinez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania 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