{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:09:43Z","timestamp":1772183383380,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study evaluates the diagnostic performance and prognostic value of brain\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodeoxyglucose (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG) positron emission tomography (PET) at the initial diagnosis of patients with nonlesional late onset epilepsy (NLLOE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cohort study at the University Hospital of Nancy, France, newly diagnosed NLLOE patients, &gt;50\u2009years old, were consecutively included from June 2017 to January 2021 and systematically underwent brain\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET. They were categorized into four presumed etiological NLLOE subtypes: neurodegenerative subtype (NDS; patients with a diagnosis of neurodegenerative disease), microvascular subtype (MVS; patients with \u22653 cardiovascular risk factors and\u2009\u22652 vascular lesions on magnetic resonance imaging), inflammatory subtype (IFS; patients meeting international criteria for encephalitis), and unlabeled subtype (ULS). A systematic patient follow\u2010up (at least 2\u2009years) allowed assessment of cognitive outcomes under antiseizure medication by comparing for each patient the proportion of preserved\/altered scores between initial and second neuropsychological assessment. Brain\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET was analyzed using a combined visual and semiquantitative approach at the individual level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010seven patients were included (NDS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918; MVS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922; IFS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097; ULS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). A normal\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET was observed in 46% of patients, with the final diagnosis of 88% of these patients excluding a neurodegenerative or inflammatory disorder.\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET had a negative predictive value of 94% for a cognitive decline at follow\u2010up, similar for the overall population (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200971) and the ULS population (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932). Moreover, a PET hypometabolic pattern suggestive of a neurodegenerative disorder was indicative of cognitive decline at follow\u2010up in 74% of cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET as part of the initial diagnosis of NLLOE patients may have a significant impact on both NLLOE diagnosis and cognitive prognosis. For almost half of NLLOE patients, a normal\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET could help to exclude neurodegenerative and inflammatory epilepsy etiologies as well as future cognitive decline.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18328","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T03:16:21Z","timestamp":1740539781000},"page":"2066-2078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brain\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    \u2010fluorodeoxyglucose positron emission tomography: An efficient tool at the initial diagnosis of nonlesional late onset epilepsy"],"prefix":"10.1111","volume":"66","author":[{"given":"Salom\u00e9","family":"Puisieux","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital of Nancy  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Heyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Nancyclotep Imaging Platform CHRU Nancy  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natacha","family":"Forthoffer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Nancy  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Doyen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Nancyclotep Imaging Platform CHRU Nancy  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0555-7150","authenticated-orcid":false,"given":"Louise","family":"Tyvaert","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Nancy  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-0328","authenticated-orcid":false,"given":"Antoine","family":"Verger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Nancyclotep Imaging Platform CHRU Nancy  Nancy France"},{"name":"University of Lorraine, Adaptive Diagnostic and Interventional Imaging, INSERM U1254  Nancy 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