{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:17:19Z","timestamp":1790140639744,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SGL030\\1029"],"award-info":[{"award-number":["SGL030\\1029"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CL\u20102022\u201007\u2010002"],"award-info":[{"award-number":["CL\u20102022\u201007\u2010002"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this concept paper, we introduce epilepsy\u2010heart syndrome\u2009as a shared burden of illness between epilepsy and cardiac disorders. This pragmatic definition is agnostic of which condition came first (the epilepsy or the cardiac disorder), recognising that these conditions can each serve as a risk factor for the other owing to a bidirectional relationship that exists between the brain and the heart. To provide clinical context, we include ictal asystole as an example phenotype of epilepsy\u2010heart syndrome. We highlight evidence of patients with ictal asystole coming to harm owing to the failure of integrated care between neurology and cardiology. This underscores epilepsy\u2010heart syndrome as an unmet need for collaborative care between neurology and cardiology. To address this, we propose a framework for integrated care, drawing upon our own centre's recently established and successful multidisciplinary team meeting (MDT) between neurologists and cardiologists, our joint cardiology\u2010neurology PhD programme, and our work developing a joint national guideline on ictal asystole management between the Association of British Neurologists (ABN) and the British Heart Rhythm Society (BHRS).<\/jats:p>","DOI":"10.1111\/epi.18356","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:00:21Z","timestamp":1741852821000},"page":"1830-1837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Epilepsy\u2013heart syndrome: Concept, clinical context, and opportunity for integrated care"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-2944","authenticated-orcid":false,"given":"Gashirai K.","family":"Mbizvo","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart and Chest Hospital  Liverpool UK"},{"name":"Pharmacology and Therapeutics, Institute of Systems, Molecular, and Integrative Biology University of Liverpool  Liverpool UK"},{"name":"Walton Centre National Health Service (NHS) Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain E.","family":"Buchan","sequence":"additional","affiliation":[{"name":"Department of Public Health, Policy, and Systems, Institute of Population Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G.","family":"Marson","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics, Institute of Systems, Molecular, and Integrative Biology University of Liverpool  Liverpool UK"},{"name":"Walton Centre National Health Service (NHS) Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart and Chest Hospital  Liverpool UK"},{"name":"Danish Center for Health Services Research, Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16966"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.106946"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.101868"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2022.108721"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.110111"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42494-024-00152-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.11.021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102014\u2010305664"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp216"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002984"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16116"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad523"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.108393"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.07.020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4997\/jrcpe.2020.230"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4997\/jrcpe.2019.209"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102015\u2010310559"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebr.2024.100696"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2011.03262.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13934"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14637"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689208501007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2015.991716"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.3424"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16420"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.09.008"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2022.2023128"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1535-7597.2004.42001.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd10100433"},{"issue":"3","key":"e_1_2_10_31_1","article-title":"Neurological consequences of cardiac arrhythmias: relationship between stroke, cognitive decline, and heart rhythm disorders","volume":"16","author":"Srinivas S","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_10_32_1","article-title":"Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia","volume":"2012","author":"Torre JC","year":"2012","journal-title":"Cardiovasc Psychiatry Neurol"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002393"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.745061"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021082"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.12.005"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2016.12.1.21"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.6.857"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9432(76)90048-0"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14084"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12692"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.07.006"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144009"},{"key":"e_1_2_10_44_1","first-page":"223","article-title":"Epilepsy and the heart","volume":"17","author":"Rugg\u2010Gunn FJ","year":"2010","journal-title":"Br J Cardiol"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2011.03266.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008077"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13979"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.07.003"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306175"},{"issue":"43","key":"e_1_2_10_50_1","first-page":"849","article-title":"Comorbidity in adults with epilepsy\u2013United States, 2010","volume":"62","author":"Centers for Disease C, Prevention","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.09.034"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32596-0"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17137"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2022.32"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht511"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:35:50Z","timestamp":1762954550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/epi.18356"],"URL":"https:\/\/doi.org\/10.1111\/epi.18356","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"assertion":[{"value":"2025-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}