{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:30Z","timestamp":1787014170433,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 NS135908"],"award-info":[{"award-number":["F31 NS135908"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00 NS097618"],"award-info":[{"award-number":["R00 NS097618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS075270"],"award-info":[{"award-number":["R01 NS075270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS108445"],"award-info":[{"award-number":["R01 NS108445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS110130"],"award-info":[{"award-number":["R01 NS110130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Surgical resection of the seizure onset zone can be an effective treatment for patients with drug\u2010resistant focal epilepsy. Clinical, electrophysiological, and imaging data are all gathered prior to surgery to localize the seizure onset zone. However, only ~62% of patients become seizure\u2010free after surgery, highlighting the need for improved methods to prospectively predict seizure recurrence after resection.\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010Fluorodeoxyglucose (FDG) positron emission tomography (PET) is routinely acquired to guide epilepsy surgery; however, these scans are often assessed qualitatively in the clinic. Here, we quantified the surgical targeting of lateralized FDG\u2010PET hypometabolism and assessed its relationship to surgical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 55 patients who underwent resective epilepsy surgery (46 with temporal lobe epilepsy). We calculated laterality of the patients' presurgical FDG\u2010PET scans and used pre\u2010 and postsurgical magnetic resonance imaging to delineate the surgically resected regions. Surgical targeting of FDG\u2010PET laterality was computed using the discriminability between resected and spared regions statistic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that surgical targeting of FDG\u2010PET laterality could distinguish temporal lobe epilepsy patients who achieve freedom from disabling seizures in the long term (3\u2009years) from those who do not (area under the curve [AUC]\u2009=\u2009.83), outperforming the standard clinical assessment (AUC\u2009=\u2009.68). We additionally found that this method generalized to the nine patients with extratemporal lobe focal epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study highlights the benefit of quantifying FDG\u2010PET to guide epilepsy surgery. The presented quantitative FDG\u2010PET method could be used prospectively in the clinic to aid in surgical guidance and patient counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18402","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:47:02Z","timestamp":1744199222000},"page":"2816-2829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgical targeting of lateralized\n                    <sup>18<\/sup>\n                    F\u2010fluorodeoxyglucose positron emission tomography hypometabolism relates to long\u2010term epilepsy surgery outcomes"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-5871","authenticated-orcid":false,"given":"Lucas E.","family":"Sainburg","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-0762","authenticated-orcid":false,"given":"Derek J.","family":"Doss","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Berry","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Roche","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre H.","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary T.","family":"Smith","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario J.","family":"Englot","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurological Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurological Surgery Vanderbilt University Medical Center  Nashville Tennessee 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