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The development of PTE was assessed from 1\u2010month\u2010long video\u2013electroencephalography (EEG) data acquired during the seventh post\u2010injury month. Diffusion magnetic resonance imaging (MRI) tractography of the optic radiation was performed using data acquired at 9\u2009days and at 5\u2009months post\u2010injury. The optic tract in each hemisphere was divided into segments, and tract and diffusion tensor\u2013based metrics were obtained for use as predictor variables (a total of 451 predictors). In the training cohort, including 17 TBI rats with (TBI+) and 66 without epilepsy (TBI\u2212) at 9\u2009days and 18 TBI+ and 69 TBI\u2212 rats at 5\u2009months, 20 predictor variables with the highest effect sizes (Cohen's delta) were selected. These variables were used with elastic net\u2013regularized logistic regression to model the development of PTE. The predictor variables chosen in the training cohort were also used for model fitting in a separate validation cohort (8 TBI+ and 23 TBI\u2212 at 9\u2009days; 9 TBI+ and 23 TBI\u2212 at 5\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the training cohort, the fitted models explained the development of PTE with (cross\u2010validated) areas under the receiver\u2010operating characteristic (ROC) curve (AUC) of 0.74 (<jats:italic>p<\/jats:italic>\u2009=\u2009.003) at 9\u2009days and 0.76 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) at 5\u2009months post\u2010TBI. Models fitted in the validation cohort achieved AUC values of 0.50 (<jats:italic>p<\/jats:italic>\u2009=\u20091) at 9\u2009days and 0.77 (<jats:italic>p<\/jats:italic>\u2009=\u2009.03) at 5\u2009months post\u2010TBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our data show that white matter pathology is involved in post\u2010traumatic epileptogenesis after lateral FPI. Moreover, imaging of thalamocortical pathway(s) to perilesional cortex could identify translational prognostic biomarkers for post\u2010traumatic epileptogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18408","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T10:42:43Z","timestamp":1747737763000},"page":"2830-2841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Damage in thalamic projection to perilesional cortex as a prognostic biomarker for experimental post\u2010traumatic epilepsy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-6079","authenticated-orcid":false,"given":"Eppu","family":"Manninen","sequence":"first","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Cabeen","sequence":"additional","affiliation":[{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"Immonen","sequence":"additional","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Ekolle","family":"Ndode\u2010Ekane","sequence":"additional","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Andrade","sequence":"additional","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1965-6750","authenticated-orcid":false,"given":"Neil G.","family":"Harris","sequence":"additional","affiliation":[{"name":"UCLA Brain Injury Research Group, Department of Neurosurgery David Geffen School of Medicine at University of California Los Angeles  Los Angeles California USA"},{"name":"Intellectual Development and Disabilities Research Center University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, the School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-5860","authenticated-orcid":false,"given":"Jussi","family":"Tohka","sequence":"additional","affiliation":[{"name":"A. 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