{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:51:53Z","timestamp":1784868713482,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The World Health Organization's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders calls for more epilepsy care centers, but a population\u2010level estimate of epilepsy's projected burden to justify this investment from a societal perspective is lacking. We aimed to project the burden of epilepsy using dynamic life table modeling including number of deaths, years of life, quality\u2010adjusted life years (QALYs), productivity\u2010adjusted life years (PALYs), health care costs, and number of people to be screened for surgical eligibility in the Australian adult population (aged 18\u201380\u2009years) from 2024 to 2033.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A dynamic model was developed to capture incident and prevalent epilepsy in Australia, using five health states: not seizure\u2010free non\u2010drug resistant (NSF\u2010NDRE), seizure\u2010free non\u2010drug resistant (SF\u2010NDRE), not seizure\u2010free drug resistant (NSF\u2010DRE), seizure\u2010free drug\u2010resistant (SF\u2010DRE), and death in 1\u2010year\u2009cycles. The inputs came from published studies, Glosgow cohort study\u00a0and from the Australian Epilepsy Project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 10\u2009years, 82\u2009723 Australian adults had incident epilepsy, whereas 125\u2009223 formed the prevalent cohort. Over 10\u2009years, the epilepsy population experienced 15\u2009227 deaths and accrued 1\u2009209\u2009280\u2009years of life, distributed as 23.6% NSF\u2010NDRE, 58.3% SF\u2010NDRE, 15.8% NSF\u2010DRE, and 2.1% SF\u2010DRE. The population accrued 992\u2009812 QALYs and 442\u2009600 PALYs. Total health care costs reached $14.2 billion US dollars (USD), of which NSF\u2010DRE contributed 35%. Uncontrolled seizures resulted in the loss of 84\u2009881 QALYs, 19\u2009333 PALYs, $4.5 billion USD, and 4603 lives. A total of 10\u2009665 individuals were eligible for surgical evaluation, with an additional 383 projected annually through 2033.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This dynamic life table model, based on the current standard of care for epilepsy, demonstrates quality of life impact, productivity loss, and cost burden due to uncontrolled seizures and drug resistance, supporting the need for further investment in epilepsy care. This approach can be applied to other countries to inform policy decisions in epilepsy from a societal perspective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18430","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T11:44:00Z","timestamp":1745927040000},"page":"2803-2815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ten\u2010year projection of adult epilepsy burden in Australia"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1203-477X","authenticated-orcid":false,"given":"Gopisankar Mohanannair","family":"Geethadevi","sequence":"first","affiliation":[{"name":"Health Economics and Policy Evaluation Research Group Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer Jarlov","family":"Jensen","sequence":"additional","affiliation":[{"name":"Health Economics and Policy Evaluation Research Group Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University  Clayton Victoria Australia"},{"name":"Copenhagen Phase IV Unit, Center for Clinical Research and Prevention, and Department of Clinical Pharmacology Copenhagen University Hospital\u2013Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-276X","authenticated-orcid":false,"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[{"name":"Neurology Department Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Clayton Victoria Australia"},{"name":"Department of Medicine Royal Melbourne Hospital, University of Melbourne  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Clayton Victoria Australia"},{"name":"Monash Institute for Medical Engineering, Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-3844","authenticated-orcid":false,"given":"Emma","family":"Foster","sequence":"additional","affiliation":[{"name":"Neurology Department Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Jackson","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Department of Neurology Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1888-6917","authenticated-orcid":false,"given":"Zhibin","family":"Chen","sequence":"additional","affiliation":[{"name":"Neurology Department Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanfina","family":"Ademi","sequence":"additional","affiliation":[{"name":"Health Economics and Policy Evaluation Research Group Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University  Clayton Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Clayton Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Australian Epilepsy Project Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Intersectoral global action plan on epilepsy and other neurological disorders.https:\/\/www.who.int\/publications\u2010detail\u2010redirect\/9789240076624. 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