{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:48:48Z","timestamp":1792637328491,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study was to investigate how the topographical map of human subjective experiences induced by intracranial electrical stimulation (iES) compares to the map of subjective auras experienced by patients during seizures involving the same cortical areas (here, the insular cortex).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 14 patients with insular epilepsies confirmed with intracranial electroencephalography in the United States (<jats:italic>N<\/jats:italic>\u2009=\u20097) and France (<jats:italic>N<\/jats:italic>\u2009=\u20097). We identified insular regions involved early in seizures (i.e., presumed seizure\u2010onset zones [SOZs]), and documented the auras reported by each patient. Data from subjective reports of auras were then compared with subjective reports during insular iES in 10 of the 14 patients with confirmed insular seizures and in 17 other patients with stimulation of normal insular sites (previously reported by our group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Epileptic auras reported by patients with seizures involving the insula were largely categorized as visceral, pain\/temperature, or non\u2010painful\/non\u2010temperature bodily sensations. We observed a striking similarity between the topographical maps of auras during insular seizures and the subjective states induced by the stimulation of the same insular regions (either identified as epileptic or not\u2010epileptic).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our findings may guide informed clinical decision\u2010making in patients with similar ictal semiology and insular lesions identified on magnetic resonance imaging. On the basis of our findings, we conclude that (1) electrically evoked and seizure\u2010induced subjective symptoms are similar when the presumed SOZ involves the insula; (2) the topography of subjective experiences evoked by insular iES and seizures is largely anatomically consistent across subjects; and (3) stimulation of radiographically abnormal brain tissue seems to cause symptoms that are similar and reliable compared to the ones evoked by the stimulation of the same site in subjects without structural insular abnormalities. The extent to which these findings can be generalized to other cortical regions and networks remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.18433","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:14:18Z","timestamp":1747116858000},"page":"2766-2778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Topographical map of subjective states evoked by focal seizures and electrical stimulation of the human insula"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4999-3945","authenticated-orcid":false,"given":"Anna","family":"Duong","sequence":"first","affiliation":[{"name":"Laboratory of Behavioral and Cognitive Neuroscience, Department of Neurology and Neurological Sciences Stanford School of Medicine  Palo Alto California 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Staalduinen","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Pantis","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral and Cognitive Neuroscience, Department of Neurology and Neurological Sciences Stanford School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u00e9not","family":"Marc","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Pierre Wertheimer Hospital University Hospital of Lyon  Lyon France"},{"name":"CRNL \u2010 INSERM U 1028\/CNRS UMR 5292, Lyon Neuroscience Research Centre Lyon 1 University  Lyon 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