{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:25:24Z","timestamp":1788539124251,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003134","name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["J.0043.20F"],"award-info":[{"award-number":["J.0043.20F"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["U.N013.21F"],"award-info":[{"award-number":["U.N013.21F"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004744","name":"Innoviris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015400","name":"Fonds Erasme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cryogenic magnetoencephalography (MEG) has a lower yield in temporal lobe epilepsy (TLE) than in extratemporal lobe epilepsy. The advent of optically pumped magnetometers (OPMs) might change this situation thanks to on\u2010scalp MEG. This study aims to investigate the detection\/localization accuracy of interictal epileptiform discharges (IEDs) using on\u2010scalp MEG in TLE and the added value of face\u2010OPMs. Eleven patients underwent a 1\u2010h MEG recording with OPMs placed both on the scalp (flexible cap, scalp\u2010OPMs) and on the face (glasseslike structure, face\u2010OPMs). Nine patients underwent cryogenic MEG. IED amplitude and signal\u2010to\u2010noise ratio (SNR) were compared when \u226510 IEDs were detected. A mean of 13 IEDs\/patient were detected using on\u2010scalp MEG (mean amplitude\u2009=\u20093.3 pT, mean SNR\u2009=\u20099.4) and localized in the (medial, anterior, basal, lateral, posterior) temporal lobe. Amplitude and SNR were either higher or similar between on\u2010scalp and cryogenic MEG, with neural sources separated by 6\u201316\u2009mm. In two patients, on\u2010scalp MEG source locations were confirmed by surgical resection cavity or stereoelectroencephalography. Face\u2010OPMs had a clear added value in one patient with anteromedial TLE. On\u2010scalp MEG can detect\/localize IEDs in TLE. Face\u2010OPMs may have added value in patients with anterior\/medial TLE and increase the spatial coverage of the temporal lobe. This study paves the way for the use of on\u2010scalp MEG in patients with refractory TLE.<\/jats:p>","DOI":"10.1111\/epi.18439","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:16:26Z","timestamp":1746188186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["On\u2010scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-4094","authenticated-orcid":false,"given":"Odile","family":"Feys","sequence":"first","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire de Bruxelles (H.U.B.), H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"},{"name":"Laboratoire de Neuroanatomie et Neuroimagerie Translationnelles, ULB Neuroscience Institute Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Wens","sequence":"additional","affiliation":[{"name":"Laboratoire de Neuroanatomie et Neuroimagerie Translationnelles, ULB Neuroscience Institute Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"},{"name":"Department of Translational Neuroimaging, H\u00f4pital Universitaire de Bruxelles (H.U.B.), H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Depondt","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire de Bruxelles (H.U.B.), H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Rikir","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire de Bruxelles (H.U.B.), H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gaspard","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire de Bruxelles (H.U.B.), H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"},{"name":"Department of Neurology Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Van Paesschen","sequence":"additional","affiliation":[{"name":"Department of Neurology Universitair Ziekenhuis Leuven, Katholieke Universiteit Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Aeby","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology H\u00f4pital Universitaire des Enfants Reine Fabiola, H\u00f4pital Universitaire de Bruxelles (H.U.B.), Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-5484","authenticated-orcid":false,"given":"Olivier","family":"Bodart","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire de Li\u00e8ge Universit\u00e9 de Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Carrette","sequence":"additional","affiliation":[{"name":"Department of Neurology Universitair Ziekenhuis Gent, Universiteit Gent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Holmes","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy Sir Peter Mansfield Imaging Centre, University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brookes","sequence":"additional","affiliation":[{"name":"School of Physics and 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