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However, it is unknown if both types of abnormalities are important in supporting seizures. Here, we test if surgical removal of GM and\/or SWM abnormalities relates to post\u2010surgical seizure outcome in people with temporal lobe epilepsy (TLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed structural imaging data from 143 patients with TLE (pre\u2010op diffusion magnetic resonance imaging and pre\u2010op T1\u2010weighted MRI) and 97 healthy controls. We calculated GM volume abnormalities and SWM mean diffusivity abnormalities and evaluated if their surgical removal distinguished seizure outcome groups post\u2010surgically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At a group level, GM and SWM abnormalities were most common in the ipsilateral temporal lobe and hippocampus in people with TLE. Analyzing both modalities together, compared to in isolation, improved surgical outcome discrimination (GM area under the curve [AUC]\u2009=\u20090.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01; WM AUC\u2009=\u20090.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01; Union AUC\u2009=\u20090.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01; Concordance AUC\u2009=\u20090.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). In addition, 100% of people who had all concordant abnormal regions resected had International League Against Epilepsy (ILAE)\n                      <jats:sub>1,2<\/jats:sub>\n                      outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Resecting abnormalities in GM or SWM individually affects surgical outcomes but combining both provides clearer patient group distinctions. This approach improves outcome differentiation, showing higher rates of patients living without disabling seizures when all concordant abnormal regions are resected. These findings suggest that regions identified as abnormal from both diffusion\u2010weighted and T1\u2010weighted MRI are involved in the epileptogenic network and that resection of both types of abnormalities may enhance the chances of living without disabling seizures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18494","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:09:44Z","timestamp":1749726584000},"page":"3688-3699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery"],"prefix":"10.1111","volume":"66","author":[{"given":"Csaba","family":"Kozma","sequence":"first","affiliation":[{"name":"CNNP Lab (www.cnnp\u2010lab.com), School of Computing Newcastle University  Newcastle upon Tyne 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