{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:01:25Z","timestamp":1792530085345,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Status epilepticus (SE) represents one of the most common neurological emergencies. The International League Against Epilepsy (ILAE) redefined SE duration thresholds from 30 to 5\u2009min for convulsive SE in 2015. We conducted a prospective population\u2010based study to determine SE incidence and outcomes under the revised criteria and compared findings with historical data using the 30\u2010min definition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, population\u2010based cohort study was conducted over a period of 18\u2009months to determine the incidence of SE in Germany, replicating the methodology of a first study conducted in this region in 1999. The study included all adults residing within the 35\u2010postcode area, with participation from all regional hospitals and emergency departments. SE cases were prospectively identified and reported. To ensure comparability with the historical data, the analysis focused on the Primary Service Area (PS\u2010Area)\u2014the direct catchment region of the University Hospital Marburg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 180 adults with SE (96 men, mean age 66.47\u2009years, SD \u00b1\u200918.5\u2009years, range: 20\u201394\u2009years). The crude annual incidence in the PS\u2010Area increased from 15.8\/100\u2009000 (95% confidence interval [CI] 11.2\u201321.6) in 1999 to 29.4\/100\u2009000 adults (95% CI 20.5\u201340.0). It was higher in men than in women (30.9 vs 28.1\/100\u2009000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.11) and in patients \u226560\u2009years (68.5 vs 13.5\/100\u2009000;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). The calculated age\u2010 and gender\u2010adjusted incidence was 32.5\/100\u2009000 in the PS\u2010Area. The case\u2013fatality rate was 5.77% (95% CI 1.2%\u201312.7%) and the crude annual cause\u2010specific mortality rate per 100\u2009000 is 1.70 (95% CI 0.21\u20134.73). In 53% SE was the first seizure episode; only 47% had a history of epilepsy. When extrapolating these findings to the entire German population, there were at least 20\u2009000 cases of SE with 1000 associated deaths annually.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>These findings provide new epidemiologic evidence that the incidence of SE has increased by ~12% with the adoption of the ILAE 2015 definition, underscoring the impact of updated diagnostic criteria on epidemiological estimates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18535","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T13:59:08Z","timestamp":1753106348000},"page":"4298-4307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of revised definitions on the epidemiology of status epilepticus: A population\u2010based study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9358-9312","authenticated-orcid":false,"given":"Meike","family":"Menche","sequence":"first","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9732-3205","authenticated-orcid":false,"given":"Clara","family":"J\u00fcnemann","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens\u2010Peter","family":"Reese","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences TH Mittelhessen University of Applied Sciences  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-3138","authenticated-orcid":false,"given":"Martin","family":"J\u00fcnemann","sequence":"additional","affiliation":[{"name":"Department for Neurology, University Hospital Giessen Justus\u2010Liebig\u2010University  Gie\u00dfen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Teepker","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"},{"name":"Hardtwald Clinic for Neurology  Bad Zwesten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Best","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"},{"name":"Vitos Clinic for Neurology  Weilm\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roth","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"},{"name":"Department of Neurology Klinikum Kassel  Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"S\u00fcnkeler","sequence":"additional","affiliation":[{"name":"BDH Clinic for Neurology  Braunfels Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Pryss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kreiskrankenhaus Frankenberg  Frankenberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-7471","authenticated-orcid":false,"given":"Felix","family":"Rosenow","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main, Center of Neurology and Neurosurgery University Medical Center Frankfurt, Goethe\u2010University Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-9915","authenticated-orcid":false,"given":"Adam","family":"Strzelczyk","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"},{"name":"Epilepsy Center Frankfurt Rhine\u2010Main, Center of Neurology and Neurosurgery University Medical Center Frankfurt, Goethe\u2010University Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-1196","authenticated-orcid":false,"given":"Leona","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-7784","authenticated-orcid":false,"given":"Lena","family":"Habermehl","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"},{"name":"Department of Epilepsy, Cleveland Medical Center University Hospitals  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-6323","authenticated-orcid":false,"given":"Panagiota\u2010Eleni","family":"Tsalouchidou","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Simon","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Kemmling","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Nimsky","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Timmermann","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Menzler","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-0513","authenticated-orcid":false,"given":"Susanne","family":"Knake","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hesse, Department for Neurology, University Hospital Marburg Philipps University  Marburg Germany"},{"name":"LOEWE\u2010Research\u2010Cluster for Advanced Medical Physics in Imaging and Therapy (ADMIT) TH Mittelhessen University of Applied Sciences  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010023\u201007263\u2010w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14478"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16277"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201052899\u20105.00029\u20100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490190019001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1999.tb02070.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"e_1_2_9_10_1","unstructured":"030079_LL_Status\u2010epilepticus_2020_V1.2. Accessed 20 Feb 2023. Available from:https:\/\/dnvp9c1uo2095.cloudfront.net\/wp\u2010content\/uploads\/2020\/08\/030079_LL_Status\u2010epilepticus_2020_V1.2.pdf"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1999.tb02000.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528\u20101157.2001.01101.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.693"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2005.01073.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528\u20101157.2003.63702.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111873"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010013\u20109935\u2010x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.7.1070"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528\u20101157.2001.0420081031.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.735"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.46.4.1029"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.04.040"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122350"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.06.009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14607"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13670"},{"key":"e_1_2_9_27_1","unstructured":"Statistisches Bundesamt.Startseite. Published December 13 2022. Accessed 2 Dec 2024. Available from:https:\/\/www.destatis.de\/DE\/Home\/_inhalt.html"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.02.027"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1064642"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10049\u2010008\u20101057\u20101"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2005.00409.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2006.00845.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.2000.tb01521.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)00042\u20103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691\u2010199512040\u201000003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.08.016"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.08.021"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12867"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010023\u201004592\u20106"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0000000000000568"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2019.12.007"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.05.007"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/ebeh.2000.0100"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106720"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fepid.2023.1081757"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00507"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17614"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13837"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010023\u201003505\u2010y"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14495"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466\u2010023\u201000261\u20109"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.11.001"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001123"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100657\u20108254"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13716"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466\u2010024\u201000348\u2010x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2024.04.005"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0609"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14106"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.18535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:39:24Z","timestamp":1785854364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/epi.18535"],"URL":"https:\/\/doi.org\/10.1111\/epi.18535","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}