{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:57:03Z","timestamp":1785855423254,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","award":["932267"],"award-info":[{"award-number":["932267"]}],"id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In patients with intractable epilepsy, accurate diaries of seizure occurrence and timing can substantially inform management. Wearable devices that provide confirmation of seizure occurrence complement such diaries, which are frequently incomplete and\/or inaccurate. Here, we combined seizure diaries and longitudinally deployed wrist\u2010worn device recordings to evaluate whether wearable recordings contain information that can discriminate between days containing seizure\u2010related activity and those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with focal seizures were prospectively enrolled in a clinical trial to test the effectiveness of eslicarbazepine acetate as an adjunct to levetiracetam or lamotrigine (phase IV clinical trial NCT03116828). One hundred two patients maintained a seizure diary and wore a biosensor for &gt;30\u2009weeks. Based on diaries, we labeled days as either \u201cseizure\u201d versus \u201cno\u2010seizure\u201d or \u201cpreseizure\u201d versus \u201cno\u2010preseizure.\u201d We compared patterns obtained by harmonic 24\u2010h modeling between conditions. Best\u2010ranking wearable markers and seizure diary variables were fed into a fully connected neural network, with several hidden layers and depth as hyperparameters that classified between seizure day conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final sample contained 70 patients (median age\u2009=\u200942.5\u2009years, 43 female) with 5437 recorded patient\u2010days, including 557 seizure days and 537 preseizure days. Twenty\u2010four\u2010hour patterns in electrodermal activity and accelerometry differentiated no\u2010seizure versus seizure days, as well as no\u2010preseizure versus preseizure days (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). Classification between no\u2010seizure and seizure days (weighted F1\u2009=\u2009.81, sensitivity\u2009=\u2009.82, specificity\u2009=\u2009.67) as well as between no\u2010preseizure and preseizure days (weighted F1\u2009=\u2009.82, sensitivity\u2009=\u2009.80, specificity\u2009=\u2009.66) revealed good performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Wearable data capture seizure\u2010related differences with daily resolution, differentiating between days with lower and higher seizure susceptibility. Combining diary\u2010based clinical and wearable data bears the potential for developing a dynamic seizure detection and prediction system with daily resolution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18550","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T15:59:26Z","timestamp":1752335966000},"page":"4259-4271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Seizure monitoring by combined diary and wearable data: A multicenter, longitudinal, observational study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-8690","authenticated-orcid":false,"given":"Solveig","family":"Vieluf","sequence":"first","affiliation":[{"name":"Division of Epilepsy and Clinical Neurophysiology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine I Ludwig Maximilian University Hospital, Ludwig Maximilian University Munich  Munich Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site, Munich Heart Alliance  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-2096","authenticated-orcid":false,"given":"Sasagu","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Sumitomo Pharma America, Inc.  Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishnav","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Neuroscience, and Psychiatry &amp; Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Bosl","sequence":"additional","affiliation":[{"name":"Data Institute, Clinical Neuroinformatics &amp; AI Laboratory University of San Francisco  San Francisco California USA"},{"name":"Computational Health Informatics Program Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Grinnell","sequence":"additional","affiliation":[{"name":"Sumitomo Pharma America, Inc.  Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Loddenkemper","sequence":"additional","affiliation":[{"name":"Division of Epilepsy and Clinical Neurophysiology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.713794"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.04.128"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17930"},{"issue":"9","key":"e_1_2_12_5_1","first-page":"2619","article-title":"Epilepsyecosystem.Org: crowd\u2010sourcing reproducible seizure prediction with long\u2010term human intracranial EEG","volume":"141","author":"Kuhlmann L","year":"2018","journal-title":"Brain"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70075-9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2022.07.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16541"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.690404"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16719"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16967"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68434-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03444.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17607"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103619"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.02.018"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30396-3"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16843"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18271-z"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae034"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2023.07.018"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25949-x"},{"key":"e_1_2_12_23_1","unstructured":"CholletF.Keras.2015. 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