{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:38:52Z","timestamp":1791409132198,"version":"4.3.3"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201020\u2010CE17\u20100025\u201001"],"award-info":[{"award-number":["ANR\u201020\u2010CE17\u20100025\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Mesial temporal lobe epilepsy (MTLE) is generally associated with cognitive and psychiatric comorbidities. Here we examined whether similar comorbidities are observed in mice injected with kainate in the dorsal hippocampus, a model known to recapitulate many features of human MTLE, and if these comorbidities are sex dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male and female C57BL\/6 mice were unilaterally injected with kainate in the dorsal hippocampus (KA\u2010MTLE), and hippocampal paroxysmal discharges were recorded over 2\u2009months. Behavioral tests assessed food intake (Novelty Palatable Food Intake test), well\u2010being (Nesting), impulsivity (Marbles test), depression\u2010related behavior (Splash test), spatial learning and memory (Barnes maze), working memory (Y\u2010maze), motor coordination (Climbing Cage test), locomotion and activity (Open Field), and anxiety\u2010like behavior (Elevated Plus Maze). Body weight and estrous cycle were also monitored and compared to saline\u2010injected mice (sham).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed reduced environmental care (Nesting) but no changes in self\u2010care (Splash test) or impulsivity (Marbles test) in KA\u2010MTLE mice. Spatial memory (Barnes maze) was unaffected, although less efficient strategies were used by these mice. Working memory (Y\u2010maze) remained similar to that of shams. No motor impairments were observed (Climbing Cage test, Open Field), but KA\u2010MTLE mice displayed increased activity without anxiety\u2010like behavior. They gained more weight, while their palatable food intake did not differ from shams, and females showed longer estrous cycles. Death that might correspond to sudden unexpected death in epilepsy (SUDEP) occurred in 10% and 3% of epileptic male and female mice, respectively, vs 0% in shams.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our results suggest that KA\u2010MTLE mice display several features (hyperactivity, reduced well\u2010being, subtle cognitive changes) evocative of an attention disorder associated with hyperactivity (attention\u2010deficit\/hyperactivity disorder [ADHD]), often described in young patients with MTLE. Along with the increase in body weight and the occurrence of SUDEP, our data further validate this mouse model to study the physiopathology of MTLE and develop treatments for both seizures and associated comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18553","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:39:06Z","timestamp":1752755946000},"page":"4525-4537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-231X","authenticated-orcid":false,"given":"Loan","family":"Samalens","sequence":"first","affiliation":[{"name":"Grenoble Institut Neurosciences Universit\u00e9 Grenoble Alpes, Inserm, U1216  Grenoble France"},{"name":"Synchrotron Radiation for Biomedecine (STROBE), Inserm UA 7  Saint Martin d'H\u00e8res France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Beets","sequence":"additional","affiliation":[{"name":"Grenoble Institut Neurosciences Universit\u00e9 Grenoble Alpes, Inserm, U1216  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-0192","authenticated-orcid":false,"given":"Clothilde","family":"Courivaud","sequence":"additional","affiliation":[{"name":"Grenoble Institut Neurosciences Universit\u00e9 Grenoble Alpes, Inserm, U1216  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-3281","authenticated-orcid":false,"given":"Philippe","family":"Kahane","sequence":"additional","affiliation":[{"name":"Grenoble Institut Neurosciences Universit\u00e9 Grenoble Alpes, Inserm, U1216  Grenoble France"},{"name":"Grenoble University Hospital  La Tronche France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-6700","authenticated-orcid":false,"given":"Antoine","family":"Depaulis","sequence":"additional","affiliation":[{"name":"Grenoble Institut Neurosciences Universit\u00e9 Grenoble Alpes, Inserm, U1216  Grenoble 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