{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:57:02Z","timestamp":1785855422066,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In people with refractory focal epilepsy, long\u2010term video\u2010electroencephalographic monitoring (LT\u2010VEEG) is a valuable tool for surgical evaluation. Antiseizure medication (ASM) is often tapered during LT\u2010VEEG. ASM reduction may increase the risk of complications such as status epilepticus, and efficacy has not been established. We characterized contributing factors to successful and safe LT\u2010VEEG within a large multicenter dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults and children were included from eight tertiary epilepsy centers in Europe for whom LT\u2010VEEG was part of the preoperative assessment for epilepsy surgery from May 2017 until January 2022. We collected demographics, baseline seizure frequency, ASM use and reductions or complete discontinuation, outcome (successful LT\u2010VEEG), and complications during ASM withdrawal\/LT\u2010VEEG. We performed multivariate regression analysis to determine factors contributing to risks of complications and successful LT\u2010VEEG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 843 people. LT\u2010VEEG was successful in 70%. ASM was tapered in 756 persons (90%). Five hundred forty\u2010four persons started reduction of ASM before LT\u2010VEEG, of whom 72% reduced it at home. Baseline seizure frequency had a strong influence on ASM withdrawal policy. In people with a lower baseline seizure frequency, ASM was more likely to be tapered, and the reduction was more often initiated before the start of the LT\u2010VEEG. The extent of ASM dose reduction was identified as a critical factor contributing to a successful LT\u2010VEEG. ASM reduction increased the chance of complications; 10% had a complication compared to 1% without reduction. Starting ASM reduction before LT\u2010VEEG did not increase the risk of complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>ASM reduction contributes to a successful LT\u2010VEEG in people with a lower baseline seizure frequency and is relatively safe, taking specific factors into account. The risk of adverse events is higher when ASM is reduced, regardless of timing or setting (outpatient vs. in\u2010hospital).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18572","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:14:11Z","timestamp":1753438451000},"page":"4490-4500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antiseizure medication reduction in long\u2010term video\u2010electroencephalographic monitoring for presurgical evaluation: A multicenter safety and efficacy analysis"],"prefix":"10.1111","volume":"66","author":[{"given":"Renate","family":"van Griethuysen","sequence":"first","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland  Heemstede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0084-9829","authenticated-orcid":false,"given":"Charlotte J. J.","family":"van Asch","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland  Heemstede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-6834","authenticated-orcid":false,"given":"Willem M.","family":"Otte","sequence":"additional","affiliation":[{"name":"Department of (Child) Neurology and Neurosurgery, member of European Reference Network EpiCARE UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herm","family":"Lamberink","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland  Heemstede the Netherlands"},{"name":"University College London Queen Square Institute of Neurology  London UK"},{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9661","authenticated-orcid":false,"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland  Heemstede the Netherlands"},{"name":"University College London Queen Square Institute of Neurology  London UK"},{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille D.","family":"Bourez\u2010Swart","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland  Heemstede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Colon","sequence":"additional","affiliation":[{"name":"Kempenhaeghe Academic Center for Epileptology  Heeze the Netherlands"},{"name":"Centre d'Etudes et Therapiede L'epilepsie, CHU\u2010Martinique  Fort\u2010de\u2010France France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees P. J.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of (Child) Neurology and Neurosurgery, member of European Reference Network EpiCARE UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the NeedtoStop Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2022.1484"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2015.05.016"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2020.106298"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02782.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12180"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.08.011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.02.004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107128"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16454"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.26401.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.06.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12179"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.01.022"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.108229"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000053748.83309.28"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106718"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.01.016"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7450"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.18572","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:38:20Z","timestamp":1785854300000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/epi.18572"],"URL":"https:\/\/doi.org\/10.1111\/epi.18572","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]},"assertion":[{"value":"2025-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}