{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:24:40Z","timestamp":1792088680898,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2054\/18"],"award-info":[{"award-number":["2054\/18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In women with epilepsy who are treated with antiseizure medications (ASMs), folate concentrations in maternal serum may not be a good indicator of fetal folate supply, because ASMs can interfere with folate handling by the placenta. We aimed to assess the transplacental folate transfer at birth in persons with epilepsy in comparison to controls with no known epilepsy and identify factors affecting it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional, two\u2010center study, involving 22 pregnant women with epilepsy treated with ASMs, 10 nontreated pregnant women with epilepsy, and 19 control pregnant individuals with no known epilepsy. Maternal venous blood and umbilical cord blood samples were collected at delivery. Folate concentrations were measured using a validated chemiluminescence assay. ASM concentrations were analyzed in serum and umbilical cord blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Maternal and neonatal characteristics were generally comparable across the study groups, but cesarian sections were more frequent among controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Folate concentrations in maternal serum were lower than recommended levels in nine of 26 (35%) of women with epilepsy and eight of 19 (42%) controls. Median cord\/maternal serum folate ratios were 1.51 (95% confidence interval [CI] = .92\u20136.35;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917) in women with epilepsy treated with ASMs and 2.02 (95% CI\u2009=\u20091.69\u20133.71;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919) in controls. In women with epilepsy, placental folate transfer was saturable (Cmax\u2009=\u2009131.1\u2009ng\/mL, 95% CI\u2009=\u200996.4\u2013190.5\u2009ng\/mL; Michaelis\u2010Menten constant, Km\u2009=\u200932.6\u2009ng\/mL, 95% CI\u2009=\u200912.5\u201376.9\u2009ng\/mL; adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.70). Predictability of cord values improved upon exclusion of preterm births (Cmax\u2009=\u2009125.2\u2009ng\/mL, 95% CI\u2009=\u200997.4\u2013164.7\u2009ng\/mL; Km =41.1\u2009ng\/mL, 95% CI\u2009=\u200922.4\u201371.1\u2009ng\/mL; adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Folate delivery to the fetus during late pregnancy is primarily explained by its concentrations in maternal circulation. In persons with epilepsy, it may be saturable. The frequent apparent folate deficiency observed in our cohort highlights the importance of folate supplementation and monitoring of its levels in maternal circulation throughout pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18575","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T14:53:18Z","timestamp":1754751198000},"page":"4752-4763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Folate transfer across the placenta during late pregnancy in women with epilepsy: A cross\u2010sectional, two\u2010center study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-7120","authenticated-orcid":false,"given":"Erez","family":"Berman","sequence":"first","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-3769","authenticated-orcid":false,"given":"Gali","family":"Pariente","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Soroka University Medical Center  Be\u2019er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5909-5235","authenticated-orcid":false,"given":"Natalia","family":"Erenburg","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-7171","authenticated-orcid":false,"given":"Roa\u2019a","family":"Hamed","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-8912","authenticated-orcid":false,"given":"Cecilie Johannessen","family":"Landmark","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Health Sciences, Oslo Metropolitan University  Oslo Norway"},{"name":"Section for Clinical Pharmacology, National Center for Epilepsy, Department of Pharmacology Oslo University Hospital  Oslo Norway"},{"name":"National Center for Epilepsy, full member of the European Reference Network EpiCARE Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-5670","authenticated-orcid":false,"given":"Michal","family":"Kovo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shamir Medical Center  Zerifin Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-6094","authenticated-orcid":false,"given":"Sara","family":"Eyal","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"David R. 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