{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:05:18Z","timestamp":1792591518352,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cenobamate (CNB) is an anti\u2010seizure medication approved for focal\u2010onset seizures in adults, with growing evidence supporting its use in pediatric drug\u2010resistant epilepsy (DRE). This study evaluates the efficacy, retention, and safety of CNB in children and adolescents, including those with developmental and epileptic encephalopathies (DEEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, multicenter study of 169 pediatric patients (0\u201318\u2009years) with DRE treated with CNB across centers in Spain. Seizure response (\u226550% reduction) and seizure freedom (no seizures in the previous month) were assessed at 3, 6, and 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 12\u2009months, CNB showed a retention rate of 89.2%, with 83.9% of patients achieving seizure response and 19.6% reaching seizure freedom. Response rates were 73.4% at 3\u2009months and 77.1% at 6\u2009months, with seizure freedom increasing from 11.8% at 3\u2009months to 21.1% at 6\u2009months. Outcomes were comparable between DEEs and focal epilepsies, indicating broad\u2010spectrum efficacy. Seizure worsening occurred in 4.7% of patients, all with DEEs. After adjusting for seizure type, those patients with focal seizures had higher odds of achieving seizure response (odds ratio [OR] 95% confidence interval [95% CI]\u00a05.46, 1.27\u201323.52;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and seizure freedom (OR\u00a095% CI 5.32, 1.57\u201317.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Median\u00a0CNB doses (mg\/kg\/day) were 1.78 (range 0.37\u201312.5), 2.5 (range 0.67\u201312.5), and 3.19 (range 0.96\u20139.09) at 3, 6, and 12\u2009months, respectively. Adverse events occurred in 44.9% of patients, most commonly somnolence (42.3%) and dizziness (22.4%), which improved with slower titration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>CNB appears effective and well\u2010tolerated in pediatric DRE, including DEE, with high retention and sustained efficacy over time. Adverse events were generally manageable with dose adjustments, and slow, weight\u2010based titration improved tolerability. Prospective studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18586","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:17:16Z","timestamp":1753888636000},"page":"4712-4724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Real\u2010world use of cenobamate in pediatric focal epilepsies and developmental epileptic encephalopathies: A multicenter retrospective series"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-2901","authenticated-orcid":false,"given":"V\u00edctor","family":"Soto\u2010Insuga","sequence":"first","affiliation":[{"name":"Hospital Universitario Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-1276","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Valls Carb\u00f3","sequence":"additional","affiliation":[{"name":"Epilepsy Unit\u2010Vithas Madrid University Hospitals  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Gretel","family":"Pinz\u00f3n\u2010Acevedo","sequence":"additional","affiliation":[{"name":"Epilepsy Unit\u2010Vithas Madrid University Hospitals  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0247-9187","authenticated-orcid":false,"given":"Elena","family":"Gonz\u00e1lez\u2010Alguacil","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9 Garc\u00eda","family":"Pe\u00f1as","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Sariego","family":"Jamardo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Aznar\u2010La\u00edn","sequence":"additional","affiliation":[{"name":"Consorci Mar Parc de Salut de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4582-6511","authenticated-orcid":false,"given":"Salvador","family":"Ib\u00e1\u00f1ez\u2010Mic\u00f3","sequence":"additional","affiliation":[{"name":"Hospital Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Alarc\u00f3n","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hospital Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Buenache","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saray","family":"Rekarte","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Parejo","family":"Olivera","sequence":"additional","affiliation":[{"name":"Epilepsy Unit\u2010Vithas Madrid University Hospitals  Madrid Spain"},{"name":"Hospital Universitario de Badajoz  Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Tuero\u2010Montiel","sequence":"additional","affiliation":[{"name":"Epilepsy Unit\u2010Vithas Madrid University Hospitals  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-7391","authenticated-orcid":false,"given":"Jana","family":"Dom\u00ednguezCarral","sequence":"additional","affiliation":[{"name":"Epilepsy Unit, Neurology Department, Coordinating Member of the ERN EpiCARE, Hospital Sant Joan de D\u00e9u, Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Santa Luc\u00eda  Cartagena Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa Garc\u00eda","family":"Ribes","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Cruces  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas Mart\u00ednez","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Cruces  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Arias","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cl\u00ednico San Carlos  Madrid 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7283-4691","authenticated-orcid":false,"given":"Virginia","family":"Navarro","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Conejo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Miravet","sequence":"additional","affiliation":[{"name":"Hospital Universitario Son Espases  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene S\u00e1nchez\u2010Miranda","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Ruber Internacional  Madrid 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