{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:18:39Z","timestamp":1787671119611,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Older voltage\u2010gated sodium channel (VGSC) blockers, such as carbamazepine and phenytoin, can increase interictal epileptiform abnormalities and induce new seizure types. However, we could find no reports for lacosamide (LCM), a newer VGSC blocker, behaving similarly in pediatric patients. We describe three pediatric patients who experienced epileptic negative myoclonus (ENM) following LCM administration. One patient had self\u2010limited epilepsy with centrotemporal spikes; the others had focal epilepsy. In all cases, interictal electroencephalography (EEG) showed unilateral or bilateral independent spike\u2010and\u2010wave discharges in the central region before LCM initiation. Concomitant medications at the time of LCM initiation included levetiracetam (Case 1), levetiracetam and valproate (Case 2), and valproate (Case 3). After LCM initiation, all patients experienced brief unilateral upper extremity muscle tone loss during wakefulness. Electromyography confirmed momentary interruption of muscle activity, time\u2010locked to the spike\u2010and\u2010wave discharges in the bilateral centrotemporal region. Hence, we determined that the movement was ENM. In addition, the interictal EEG worsened and showed bilateral synchronous spike\u2010and\u2010waves in all cases. ENM disappeared after the discontinuation of LCM. LCM can induce ENM, and the exacerbation seen in EEG due to LCM may have induced ENM. Patients should be monitored carefully for worsening of EEG findings or inducing other types of seizures.<\/jats:p>","DOI":"10.1111\/epi.18595","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T12:33:43Z","timestamp":1754656423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Suspected induction of epileptic negative myoclonus after lacosamide initiation"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-9487","authenticated-orcid":false,"given":"Naohiro","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nara Prefecture General Medical Center  Nara Japan"},{"name":"Department of Pediatric Neurology and Neurolinguistics Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-6320","authenticated-orcid":false,"given":"Ichiro","family":"Kuki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Neurolinguistics Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Neurolinguistics Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Neurolinguistics Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Neurolinguistics Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Shide\u2010Moriguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Prefecture General Medical Center  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Prefecture General Medical Center  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0441-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510103131503"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(99)00054-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000843"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60456-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.01.022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2016.09.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2013.0565"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2006.12.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(03)00327-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/026990500421949"},{"key":"e_1_2_10_13_1","first-page":"137","article-title":"Asterixis: one type of negative myoclonus","volume":"43","author":"Young RR","year":"1986","journal-title":"Adv Neurol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130195.62670.A6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1684\/j.1950-6945.2004.tb00076.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.30000.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1684\/j.1950-6945.2006.tb00159.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.10.024"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84628-644-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17241"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02210.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000159955.87511.bc"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.104968"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000205422"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213554"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh661"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84882-128-6_31"},{"key":"e_1_2_10_28_1","first-page":"295","volume-title":"Handbook of Clinical Neurology","author":"Wu S","year":"2023"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.18595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:24:09Z","timestamp":1772983449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/epi.18595"],"URL":"https:\/\/doi.org\/10.1111\/epi.18595","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"2025-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}