{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:40:41Z","timestamp":1789681241969,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sleep disturbances and epilepsy are closely interrelated. This study aimed to examine associations between sleep quality, affective symptoms, and quality of life (QoL) in people with epilepsy (PWE), and to identify clinical and sociodemographic factors linked to impaired sleep.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter cross\u2010sectional study of adult PWE across four tertiary epilepsy centers in Germany. We assessed sleep quality using the Pittsburgh Sleep Quality Index (PSQI), affective symptoms with the Hospital Anxiety and Depression Scale (HADS), and epilepsy\u2010specific QoL with the 31\u2010item Quality of Life in Epilepsy (QOLIE\u201031) inventory. We evaluated sociodemographic and clinical predictors of sleep quality and QoL using univariable and multivariable analyses. Comparisons were made with normative data from the general German population and individuals with chronic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 449 individuals (mean age 39.9\u2009years, 58.1% women), 221 (49.2%) were identified as \u201cpoor sleepers,\u201d significantly exceeding rates in the general population (35.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). In multivariable analysis, poor sleep quality was independently associated with female sex (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.36\u20133.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001), unemployment (OR 1.74, 95% CI\u2009=\u20091.10\u20132.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.017), anxiety (OR\u2009=\u20093.79, 95% CI\u2009=\u20092.39\u20136.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and depression (OR\u2009=\u20092.19, 95% CI\u2009=\u20091.36\u20133.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001). In addition, daily seizures were linked to worse sleep quality (OR\u2009=\u20092.55, 95% CI\u2009=\u20091.03\u20136.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.042). Poor sleep was independently associated with lower epilepsy\u2010related QoL after adjusting for affective symptoms and seizure frequency (OR\u2009=\u20091.79, 95% CI\u2009=\u20091.20\u20132.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Sleep quality in PWE is significantly impaired and strongly associated with anxiety, depression, and sociodemographic variables in addition to epilepsy\u2010specific factors. Poor sleep independently correlates with diminished QoL, supporting the value of routine screening for affective symptoms and sleep disturbances in epilepsy care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18599","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T13:48:46Z","timestamp":1755870526000},"page":"4764-4779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sleep quality and its correlates in people with epilepsy: A multicenter cross\u2010sectional study in Germany"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-2562","authenticated-orcid":false,"given":"Johann Philipp","family":"Z\u00f6llner","sequence":"first","affiliation":[{"name":"Goethe University Frankfurt, Epilepsy Center Frankfurt Rhine\u2010Main, Department of Neurology University Medicine Frankfurt  Frankfurt am Main Germany"},{"name":"Goethe University Frankfurt, Center for Personalized Translational Epilepsy Research (CePTER)  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-2631","authenticated-orcid":false,"given":"Catrin","family":"Mann","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, Epilepsy Center Frankfurt Rhine\u2010Main, Department of Neurology University Medicine Frankfurt  Frankfurt am Main Germany"},{"name":"Goethe University Frankfurt, Center for Personalized Translational Epilepsy Research (CePTER)  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-1674","authenticated-orcid":false,"given":"Laurent","family":"Willems","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, Epilepsy Center Frankfurt Rhine\u2010Main, Department of Neurology University Medicine Frankfurt  Frankfurt am Main Germany"},{"name":"Goethe University Frankfurt, Center for Personalized Translational Epilepsy Research (CePTER)  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3134-8697","authenticated-orcid":false,"given":"Felix","family":"von Podewils","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology University Hospital Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Langenbruch","sequence":"additional","affiliation":[{"name":"Epilepsy Center M\u00fcnster\u2010Osnabr\u00fcck, Department of Neurology with Institute of Translational Neurology University of M\u00fcnster  M\u00fcnster Germany"},{"name":"Department of Neurology Klinikum Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-690X","authenticated-orcid":false,"given":"Laura","family":"Bierhansl","sequence":"additional","affiliation":[{"name":"Epilepsy Center M\u00fcnster\u2010Osnabr\u00fcck, Department of Neurology with Institute of Translational Neurology University of M\u00fcnster  M\u00fcnster Germany"},{"name":"Department of Neurology University Medical Center Schleswig\u2010Holstein, Campus L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Knake","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hessen, Department of Neurology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Menzler","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hessen, Department of Neurology Philipps\u2010University Marburg  Marburg 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