{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:55:25Z","timestamp":1785243325729,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated whether complete blood count (CBC) analyses during intensive care unit stay could predict 12\u2010month outcomes in patients with cryptogenic febrile infection\u2013related epilepsy syndrome (FIRES), a subset of new\u2010onset refractory status epilepticus (NORSE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Outcomes at 12\u2009months were classified as \u201cunfavorable\u201d (Glasgow Outcome Score [GOS] 1\u20133) or \u201cfavorable\u201d (GOS 4\u20135). Demographic, clinical, and serial CBC data were collected across treatment phases: (1) no immunotherapy (before initiation or no treatment), (2) first\u2010line immunotherapy, and (3) second\u2010line immunotherapy. For each treatment phase, predictive models stratified outcomes based on CBC features using decision tree regression, with separate models for adults and children. Model performance was tested using a leave\u2010one\u2010patient\u2010out approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We studied 63 patients (34 adults, 29 children) from 12 centers. Unfavorable outcomes occurred in 18 adults and 12 children. Children were more likely to receive second\u2010line immunotherapy. We analyzed 1530 CBCs (adults: 997 CBCs, including 539 for unfavorable outcomes; children: 533 CBCs, including 415 for unfavorable outcomes). Subgroup analyses revealed differences in CBC levels according to the outcomes and the treatment received. Adults with unfavorable outcomes notably had higher neutrophil\u2010to\u2010lymphocyte ratios (NLRs) and monocyte\u2010to\u2010lymphocyte ratios (MLRs), whereas children with unfavorable outcomes had higher red cell distribution width. NLRs and MLRs increased when CBCs were collected after the initiation of immunotherapy for both adults and children. The variables of interest differed in the different predictive models but always included the proportion of at least one subtype of leukocyte. Prediction accuracy with our models was higher in children (87% overall, with the best performance in no\u2010treatment and first\u2010line phases) than in adults (83% overall, with the best performance during\/after the initiation of second\u2010line).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Findings suggest the potential for standard CBCs to serve as a rapid, accessible tool for early prognostication in cryptogenic FIRES, particularly in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18605","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T14:05:19Z","timestamp":1755871519000},"page":"4780-4794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Standard complete blood count to predict long\u2010term outcomes in febrile infection\u2013related epilepsy syndrome (FIRES): A multicenter study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2523-8712","authenticated-orcid":false,"given":"Martin","family":"Guillemaud","sequence":"first","affiliation":[{"name":"Institut du Cerveau, Paris Brain Institute, ICM, INRIA, Inserm, CNRS, AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-9998","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Hanin","sequence":"additional","affiliation":[{"name":"Institut du Cerveau, Paris Brain Institute, ICM, INRIA, Inserm, CNRS, AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"},{"name":"Department of Metabolic Biochemistry AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Facult\u00e9 de Pharmacie Universite Paris Cit\u00e9  Paris France"},{"name":"Department of Neurology, Comprehensive Epilepsy Center Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Riviello","sequence":"additional","affiliation":[{"name":"Division of Neurology and Developmental Neuroscience Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-4833","authenticated-orcid":false,"given":"Mario","family":"Chavez","sequence":"additional","affiliation":[{"name":"Institut du Cerveau, Paris Brain Institute, ICM, INRIA, Inserm, CNRS, AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-5801","authenticated-orcid":false,"given":"Ayush","family":"Batra","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1109-7296","authenticated-orcid":false,"given":"Francesca","family":"Bisulli","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Delle Scienze Neurologiche di Bologna\u2014Full Member of the ERN EpiCARE  Bologna Italy"},{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5228-8574","authenticated-orcid":false,"given":"Carlos","family":"Castillo\u2010Pinto","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Seattle Children's Hospital University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Cobos\u2010Hernandez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Neurology University of Colorado School of Medicine, Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-6472","authenticated-orcid":false,"given":"Sophie","family":"Demeret","sequence":"additional","affiliation":[{"name":"Neuro\u2010Intensive Care Unit, Department of Neurology, AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-338X","authenticated-orcid":false,"given":"Krista","family":"Eschbach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Neurology University of Colorado School of Medicine, Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-7703","authenticated-orcid":false,"given":"Raquel","family":"Farias\u2010Moeller","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical College of Wisconsin, Children's Hospital of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-4153","authenticated-orcid":false,"given":"Madeline","family":"Fields","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-6723","authenticated-orcid":false,"given":"Nicolas","family":"Gaspard","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Epilepsy Center Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Neurology, H\u00f4pital Universitaire de Bruxelles\u2014H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-8360","authenticated-orcid":false,"given":"Elizabeth E.","family":"Gerard","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-4884","authenticated-orcid":false,"given":"Teneille E.","family":"Gofton","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry, London Health Sciences Center Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-3258","authenticated-orcid":false,"given":"Margaret T.","family":"Gopaul","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Epilepsy Center Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0601-7169","authenticated-orcid":false,"given":"Matthew D.","family":"Gruen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Epilepsy Center Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8706-5423","authenticated-orcid":false,"given":"Anthony D.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Epilepsy Center Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-601X","authenticated-orcid":false,"given":"Karnig","family":"Kazazian","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry, London Health Sciences Center Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2720-1940","authenticated-orcid":false,"given":"Minjee","family":"Kim","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Mansour","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Marcuse","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-0623","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Marois","sequence":"additional","affiliation":[{"name":"Neuro\u2010Intensive Care Unit, Department of Neurology, AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-4576","authenticated-orcid":false,"given":"Mikaela","family":"Morales","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Seattle Children's Hospital University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-0099","authenticated-orcid":false,"given":"Lorenzo","family":"Muccioli","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Delle Scienze Neurologiche di Bologna\u2014Full Member of the ERN EpiCARE  Bologna Italy"},{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-455X","authenticated-orcid":false,"given":"Elena","family":"Pasini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Delle Scienze Neurologiche di Bologna\u2014Full Member of the ERN EpiCARE  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-334X","authenticated-orcid":false,"given":"Santiago Philibert","family":"Rosas","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-1798","authenticated-orcid":false,"given":"Aaron F.","family":"Struck","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6208-5035","authenticated-orcid":false,"given":"Nathan","family":"Torcida","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire de Bruxelles\u2014H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-7462","authenticated-orcid":false,"given":"Mark S.","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Seattle Children's Hospital University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7242-9779","authenticated-orcid":false,"given":"Ji Yeoun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-6129","authenticated-orcid":false,"given":"Eyal","family":"Muscal","sequence":"additional","affiliation":[{"name":"Division of Neurology and Developmental Neuroscience Baylor College of Medicine  Houston Texas USA"},{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-8114","authenticated-orcid":false,"given":"Vincent","family":"Navarro","sequence":"additional","affiliation":[{"name":"Institut du Cerveau, Paris Brain Institute, ICM, INRIA, Inserm, CNRS, AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"},{"name":"Epilepsy Unit and Department of Clinical Neurophysiology, ERN\u2010Epicare, AP\u2010HP, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-832X","authenticated-orcid":false,"given":"Lawrence J.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Epilepsy Center Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9450-5506","authenticated-orcid":false,"given":"Yichen","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25439"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24806"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25374"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51308"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309388"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14524"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26627"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51755"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51714"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14016"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_543_18"},{"key":"e_1_2_14_13_1","volume-title":"Classification and regression trees","author":"Breiman L","year":"2025"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2017.11.077"},{"key":"e_1_2_14_15_1","volume-title":"The elements of statistical learning: data mining, inference, and prediction","year":"2025"},{"key":"e_1_2_14_16_1","volume-title":"Encyclopedia of statistics in behavioral science","year":"2025"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200403"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1426051"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200259"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1100551"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2024-334285"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11101881"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.04.012"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03576.x"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-025-03300-y"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03986-5"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032130"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70441"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14596"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.17712\/nsj.2023.2.20220135"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05374-w"},{"key":"e_1_2_14_32_1","unstructured":"Kineret\u00ae (anakinra) for injection for subcutaneous use."},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17933"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31821b85c6"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11351"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.521766"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00679.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.18605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.18605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:01:12Z","timestamp":1779109272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.18605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/epi.18605"],"URL":"https:\/\/doi.org\/10.1111\/epi.18605","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"assertion":[{"value":"2025-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}