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Here, we characterized a novel\n                      <jats:italic>Grin2b<\/jats:italic>\n                      heterozygous knockout rat model with electroencephalography (EEG) and pharmacological interventions to block spontaneous seizures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Through western blot analysis we assessed the extent of GluN2B\u00a0protein knockdown in knockout (\n                      <jats:italic>Grin2b<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>+\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      ) rats compared to controls. We recorded 24\u2010h wireless multi\u2010channel EEG to test whether seizure activity was present and analyzed sleep\u2013wake cycles through a novel automated sleep\u2010scoring algorithm. We tested the effects of systemic and intracerebral reticular thalamic nucleus administration of ethosuximide, a T\u2010type voltage\u2010gated calcium channel blocker, and memantine, a noncompetitive NMDAR antagonist, on seizures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to wild\u2010type rats,\n                      <jats:italic>Grin2b<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>+\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      rats had a higher incidence of spontaneous spike and wave discharges (SWDs), the electrographic correlate of absence seizures. SWDs were longer in duration and displayed higher delta band spectral power in\n                      <jats:italic>Grin2b<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>+\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      animals. Heterozygous animals displayed a reduction in total rapid eye movement sleep and altered distributions of non\u2013rapid eye movement sleep and wake epochs. This was accompanied by a decrease in overall spectral wake power and an increase in beta band power during non\u2013rapid eye movement sleep. The sleep\u2013wake phenotypes were largely uncorrelated with the incidence of SWDs. Systemic ethosuximide reduced the number and duration of SWDs, whereas memantine only reduced their duration. Intrathalamic infusion of both ethosuximide and memantine reduced the number of SWDs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      Our data show that the new rat\n                      <jats:italic>Grin2b<\/jats:italic>\n                      haploinsufficiency model exhibits clinically relevant phenotypes and highlights two potential therapeutic options for\n                      <jats:italic>GRIN2B<\/jats:italic>\n                      \u2010related epilepsy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18606","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:48:31Z","timestamp":1755596911000},"page":"4996-5013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Absence seizures and sleep\u2013wake abnormalities in a rat model of\n                    <i>GRIN2B<\/i>\n                    neurodevelopmental disorder"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4079-8676","authenticated-orcid":false,"given":"Katerina","family":"Hristova","sequence":"first","affiliation":[{"name":"Simons Initiative for the Developing Brain, Patrick Wild Centre, Institute for Neuroscience and Cardiovascular Research University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-5478","authenticated-orcid":false,"given":"Melissa C. 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