{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:42:34Z","timestamp":1791225754457,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hypothalamic hamartomas (HHs) lead to refractory epilepsy, and minimally invasive surgical approaches are standard of care for affected patients. Stereotactic radiofrequency thermocoagulation (SRT) is one of the treatment methods recognized to achieve seizure freedom. This study reports surgical outcome from a single center reporting an ablation technique using fewer trajectories than previously reported and assesses the effect of coagulated volume on long\u2010term seizure freedom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis was made of all patients who underwent SRT at the University of Freiburg between 2016 and 2024 with a follow\u2010up of \u226512\u2009months. Statistical analysis was made of outcome dependent on type of hamartoma, seizure type, coagulation volume (based on magnetic resonance imaging evaluation), and epilepsy duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010three patients received SRT; 35 (22 children) had &gt;12\u2009months of follow\u2010up, with a median of 38\u2009months. Nine patients had two SRTs, and two patients had three SRTs. Twelve\u2009months after their last SRT, 60% of patients were seizure\u2010free, 88.6% were free of bilateral tonic\u2013clonic seizures, and 77.1% were free of gelastic seizures (last follow\u2010up: 54.3% seizure\u2010free, 88.6% free of bilateral tonic\u2013clonic seizures, 74.3% free of gelastic seizures). There was a significant reduction of antiseizure medication (ASM) postsurgically, with an average number of ASMs of two prior to surgery and one after surgery. After 12\u2009months, 14.3% of patients experienced ongoing but mostly mild surgical complications, with hypothalamic dysfunction being the most common. Coagulation volumes were higher in larger HHs, but no correlation was observed between coagulated volume and seizure freedom or complication rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>SRT is a minimally invasive method to successfully treat refractory seizures in patients with HH. Disconnection seems to be more important for successful treatment than volume reduction. Even large HHs can be successfully treated with small coagulation volumes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18660","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T08:01:16Z","timestamp":1759305676000},"page":"96-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term outcomes of stereotactic radiofrequency ablation in hypothalamic hamartomas: A single\u2010center experience"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1691-546X","authenticated-orcid":false,"given":"Peter Christoph","family":"Reinacher","sequence":"first","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"},{"name":"Fraunhofer Institute for Laser Technology  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics and Muscular Disorders Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"},{"name":"Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesch Johannes","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-1110","authenticated-orcid":false,"given":"Theo","family":"Demerath","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-1684","authenticated-orcid":false,"given":"Kathrin","family":"Wagner","sequence":"additional","affiliation":[{"name":"Epilepsy Center Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"},{"name":"Member of the European Reference Network for rare and complex epilepsies EpiCARE  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-6560","authenticated-orcid":false,"given":"Victoria","family":"San Antonio\u2010Arce","sequence":"additional","affiliation":[{"name":"Epilepsy Center Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"},{"name":"Member of the European Reference Network for rare and complex epilepsies EpiCARE  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-4807","authenticated-orcid":false,"given":"Horst","family":"Urbach","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker Arnd","family":"Coenen","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery Medical Center\u2013University of Freiburg, Faculty of Medicine\u2013University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-0506","authenticated-orcid":false,"given":"Andreas","family":"Schulze\u2010Bonhage","sequence":"additional","affiliation":[{"name":"Epilepsy Center Medical Center\u2013University of Freiburg, 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