{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:22:03Z","timestamp":1791256923833,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis aimed to compare neuropsychological outcomes following traditional surgical approaches and magnetic resonance\u2010guided laser interstitial thermal therapy (MRgLITT) in patients with drug\u2010resistant mesial temporal lobe epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010four studies were included; 24 reported cognitive outcomes following open resection, seven following MRgLITT, and three reported on both procedures. Meta\u2010analyses of proportions, subgroup comparisons, and meta\u2010regressions were conducted across three cognitive domains: verbal memory, visual memory, and naming, stratified by surgical laterality and procedure type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In left\u2010sided surgery, verbal memory decline occurred in 36% (95% confidence interval [CI] =\u200928%\u201345%) after open resection and 29% (95% CI\u2009=\u20099%\u201362%) after MRgLITT, with no significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.5967). For right\u2010sided procedures, visual memory decline was similar between open resection (16%, 95% CI\u2009=\u20098%\u201329%) and MRgLITT (19%, 95% CI\u2009=\u20093%\u201361%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.8027). Left\u2010sided naming decline was higher after open resection (43%, 95% CI\u2009=\u200927%\u201361%) than MRgLITT (9%, 95% CI\u2009=\u20093%\u201322%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), a difference supported in subgroup and meta\u2010regression analyses. Exploratory meta\u2010regression suggested a borderline association between higher seizure freedom and greater naming decline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0508), but MRgLITT retained a protective effect after adjusting for seizure outcomes (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.36, 95% CI = \u22122.20 to \u2212.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0016). Regardless of the approach, naming improvement occurred in 27% of patients in each group after right\u2010sided surgery, indicating substantial recovery when the left hemisphere is preserved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Verbal memory showed a nonsignificant trend toward better preservation with MRgLITT, whereas visual memory was comparable across approaches. MRgLITT significantly preserved naming after left\u2010sided surgery, offering a clear cognitive benefit over traditional open resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.18687","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T15:55:08Z","timestamp":1760802908000},"page":"588-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neuropsychological outcomes comparing traditional surgical approaches and laser interstitial thermal therapy for refractory mesial temporal lobe epilepsy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"67","author":[{"given":"Konstantina","family":"Stavrogianni","sequence":"first","affiliation":[{"name":"Second Department of Neurology Attikon University Hospital, National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Physiology, Faculty of Medicine, School of Health 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Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Gorny","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hessen, Department of Neurology Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis","family":"Kalyvas","sequence":"additional","affiliation":[{"name":"Second Department of Neurosurgery Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lampis","family":"Stavrinou","sequence":"additional","affiliation":[{"name":"Second Department of Neurosurgery Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Giannopoulos","sequence":"additional","affiliation":[{"name":"Second Department of 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