{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:38:01Z","timestamp":1774442281781,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1F32DC020644"],"award-info":[{"award-number":["1F32DC020644"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NS122927"],"award-info":[{"award-number":["1R01NS122927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UE5NS134521"],"award-info":[{"award-number":["1UE5NS134521"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Temporal lobectomy is effective for drug\u2010resistant temporal lobe epilepsy (TLE), but broad resections risk neuropsychological morbidity. Stereo\u2010electroencephalography (SEEG) supports hypothesis\u2010driven exploration of seizure networks, where semiology\u2014together with imaging, scalp EEG, and neuropsychology\u2014anchors implantation strategies without serving as a sole classifier. We aimed to define common SEEG implantation patterns in TLE from a stereotaxic functional\u2013anatomic perspective and test their reproducibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 72 patients (60 main, 12 validation) with drug\u2010resistant TLE who underwent SEEG. Implantation strategies converged into four reproducible patterns \u2014mesial\u2010lateral temporal, temporal\u2010basal\u2010occipital, anterior perisylvian, and perisylvian\u2014guided primarily by non\u2010invasive data with semiology exerting the greatest influence. Seizure semiology, neuroimaging, and electrophysiological recordings were systematically collected. To evaluate the reproducibility of implantation patterns, machine learning classifiers (Na\u00efve Bayes, random forests) were trained to predict implantation classification based on semiological features and electrode coverage. Surgical and neuropsychological outcomes were assessed prospectively at 1\u2009year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Classification based on semiology alone achieved moderate accuracy in predicting outcomes (precision 66%, recall 65%). Electrode coverage provided substantially higher predictive power (precision 87%, recall 85%). Crucially, semiological features showed strong concordance with the actual electrode implantation patterns (precision 84%, recall 82%), demonstrating that semiology functions as a reproducible heuristic for guiding implantation strategy. Following SEEG, 94% of patients proceeded to definitive therapy (82% tailored resection, 12% neuromodulation), with a 1\u2010year seizure\u2010freedom rate of 73%, independent of lesion status or implantation category. Postoperatively, 26% of resection patients demonstrated verbal memory decline, more frequently after left\u2010sided (38%) than right\u2010sided (7.7%) interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study characterizes reproducible SEEG implantation patterns in TLE, viewed from a stereotactic functional\u2013anatomic perspective and informed by semiology. Computational analyses were used to examine the consistency of these patterns, offering insights into how implantation strategies relate to network localization and potential surgical approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.70009","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T13:58:19Z","timestamp":1763128699000},"page":"1102-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A semiology\u2010driven framework for explorations of temporal lobe epilepsy"],"prefix":"10.1111","volume":"67","author":[{"given":"Arka N.","family":"Mallela","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine, Department of Neurological Surgery  Pittsburgh Pennsylvania USA"},{"name":"Rush University Medical Center, Department of Neurological Surgery  Chicago Illinois 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thandar","family":"Aung","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Department of Neurology  Pittsburgh Pennsylvania USA"},{"name":"University of Pittsburgh Epilepsy Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle R.","family":"Carns","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Department of Neurology  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke C.","family":"Henry","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Department of Neurological Surgery  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9936-7034","authenticated-orcid":false,"given":"Jorge 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