{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:19:36Z","timestamp":1789773576741,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","award":["JPMH23FC1013"],"award-info":[{"award-number":["JPMH23FC1013"]}],"id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24wm0625207"],"award-info":[{"award-number":["JP24wm0625207"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to investigate the longitudinal volumetric changes of the contralateral hemisphere following hemispherotomy in patients with Sturge\u2013Weber syndrome (SWS) and to evaluate their association with neurodevelopmental outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 33 pediatric patients with SWS who underwent hemispherotomy and had at least one follow\u2010up magnetic resonance imaging (MRI) at 6, 12, or 24\u2009months postoperatively. Cortical volume of the contralateral (nonsurgical) hemisphere was measured on 3\u2010T MRI using SPM12 segmentation, and the volumetric increase rate was calculated. Associations between cortical volume and clinical factors, including age at surgery and seizure outcome, were examined using a linear mixed\u2010effects model. We evaluated the relationships between the cortical volume of the contralateral hemisphere and the acquisition of neurodevelopmental milestones (standing, walking, single words, and sentences). Healthy age\u2010 and sex\u2010matched controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) were included for comparison.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Contralateral cortical volume significantly increased over time following hemispherotomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). Earlier hemispherotomy was associated with greater volumetric growth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), independent of patient age at postoperative MRI acquisition. Patients with larger age\u2010adjusted cortical volumes exhibited earlier acquisition of standing and walking (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u2212.70 and \u2212.63, respectively). No significant correlation was observed between cortical hypertrophy and seizure outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study demonstrates that the contralateral hemisphere undergoes time\u2010dependent hypertrophy following hemispherotomy in patients with SWS. Early hemispherotomy may enhance this structural plasticity and contribute to improved neurodevelopmental outcomes. Longitudinal volumetric analysis of the contralateral hemisphere may serve as a surrogate biomarker of structural reorganization and a valuable tool to guide the optimal timing of surgical intervention in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.70029","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T14:31:12Z","timestamp":1763735472000},"page":"1159-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cortical hypertrophy of the contralateral hemisphere after hemispherotomy in children with Sturge\u2013Weber syndrome: A longitudinal volumetric study"],"prefix":"10.1111","volume":"67","author":[{"given":"Yasushi","family":"Iimura","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Juntendo University  Tokyo Japan"},{"name":"Epilepsy Center Juntendo University Hospital  Tokyo 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