{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:49:23Z","timestamp":1787060963131,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201016\u2010CONV000X"],"award-info":[{"award-number":["ANR\u201016\u2010CONV000X"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010EURE\u20100029"],"award-info":[{"award-number":["ANR\u201017\u2010EURE\u20100029"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thalamic deep brain stimulation (DBS) represents an emerging therapeutic option for patients with focal drug\u2010resistant epilepsy who are ineligible for or have failed resective surgery. To optimize outcomes and guide DBS lead placement, thalamic stereoelectroencephalography (SEEG) has been proposed. This monocentric retrospective study aimed to identify interictal and ictal SEEG biomarkers of the medial pulvinar (PuM) associated with favorable PuM\u2010DBS response. Six patients (four female, two male) underwent SEEG including PuM sampling, were deemed unsuitable for resective surgery, and subsequently received bilateral PuM\u2010DBS. In total, eight PuMs were sampled in SEEG: four bilaterally (two patients) and four unilaterally (four patients). The SEEG exploration covered both the PuM and the ipsilateral epileptogenic zone network (EZN) in four patients, whereas in the other two the EZN was bilateral but PuM sampling was unilateral. All SEEG signal analyses were performed on the PuM sampling contacts available in each patient. Interictal SEEG analysis included spike rates and nonlinear functional connectivity (h2), whereas ictal analyses combined visual inspection with quantitative biomarkers: epileptogenicity index (EI), connectivity epileptogenicity index (cEI), permutation entropy index (PEI), and delta entropy (\u0394E). Two patients were responders (\u226550% seizure reduction at 1\u2009year). PuM spike rates, connectivity, and EI and cEI values did not differentiate responders from nonresponders. In contrast, entropy\u2010based measures were significantly higher in responders: PEI (false discovery rate [FDR]\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.024) and \u0394E (FDR\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.034). These findings suggest that ictal PuM complexity disruption, quantified through entropy\u2010based SEEG metrics (PEI and \u0394E), may represent a candidate biomarker of response to medial pulvinar DBS and warrants validation in larger cohorts.\n                  <\/jats:p>","DOI":"10.1111\/epi.70046","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:50:19Z","timestamp":1764841819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medial pulvinar stereoelectroencephalographic biomarkers associated with deep brain stimulation response in focal drug\u2010resistant epilepsy"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-8927","authenticated-orcid":false,"given":"Ionu\u021b\u2010Flavius","family":"Bratu","sequence":"first","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute, French National Institute of Health and Medical Research (UMR 1106) Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-7406","authenticated-orcid":false,"given":"Romain","family":"Carron","sequence":"additional","affiliation":[{"name":"Systems Neuroscience Institute, French National Institute of Health and Medical Research (UMR 1106) Aix\u2010Marseille University  Marseille France"},{"name":"Medico\u2010Surgical Unit of Epileptology, Functional and Stereotactic Neurosurgery Timone Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0580-9453","authenticated-orcid":false,"given":"Audrey","family":"Clement","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-701X","authenticated-orcid":false,"given":"Samuel Medina","family":"Villalon","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute, French National Institute of Health and Medical Research (UMR 1106) Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-0297","authenticated-orcid":false,"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute, French National Institute of Health and Medical Research (UMR 1106) Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6345-1288","authenticated-orcid":false,"given":"Francesca","family":"Pizzo","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute, French National Institute of Health and Medical Research (UMR 1106) Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106045"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad121"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210039"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2025.06.012"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","unstructured":"SimpsonHD KremenV SladkyV et\u00a0al.Thalamocortical seizure onset patterns in drug resistant focal epilepsy.medRxiv. 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