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We focus on phenotypes mediated by peptide and steroid hormones (especially oxytocin and testosterone) because such hormones centrally mediate patterns of physical and behavioral resource allocation that underlie both forms of conflict. In early development, a suite of imprinted genes modulates the human oxytocinergic system as predicted from theory, with paternally inherited gene expression associated with higher oxytocin production, and increased solicitation to mothers by infants. This system is predicted to impact health through the incompatibility of paternal\u2010gene and maternal\u2010gene optima and increased vulnerability of imprinted gene systems to genetic and epigenetic changes. Early alterations to oxytocinergic systems have long\u2010term negative impacts on human psychological health, especially through their effects on attachment and social behavior. In contrast to genomic imprinting, which generates maladaptation along an axis of mother\u2013infant attachment, sexual antagonism is predicted from theory to generate maladaptation along an axis of sexual dimorphism, modulated by steroid and peptide hormones. We describe evidence of sexual antagonism from studies of humans and other animals, demonstrating that sexually antagonistic effects on sex\u2010dimorphic phenotypes, including aspects of immunity, life history, psychology, and behavior, are commonly observed and lead to forms of maladaptation that are demonstrated, or expected, to impact human health. Recent epidemiological and psychiatric studies of schizophrenia in particular indicate that it is mediated, in part, by sexually antagonistic alleles. The primary implication of this review is that data collection focused on (i) effects of imprinted genes that modulate the oxytocin system, and (ii) effects of sexually antagonistic alleles on sex\u2010dimorphic, disease\u2010related phenotypes will lead to novel insights into both human health and the evolutionary dynamics of genomic conflicts.<\/jats:p>","DOI":"10.1111\/eva.12244","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T06:53:35Z","timestamp":1420786415000},"page":"307-325","source":"Crossref","is-referenced-by-count":18,"title":["Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone"],"prefix":"10.1111","volume":"8","author":[{"given":"Mikael","family":"Mokkonen","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Simon Fraser University Burnaby BC Canada"},{"name":"Department of Biological and Environmental Science University of Jyv\u00e4skyl\u00e4 Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Crespi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Simon Fraser University Burnaby BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.09.013"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.10.007"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evt145"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00263-7"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00185"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.06.001"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1268-2"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0277"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001081"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(96)00018-7"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.097899"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00048"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2013.2002"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2008.12.005"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911700107"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2011.01.002"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.09.005"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi008"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20771"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01623.x"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.4159\/9780674029118"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.08.025"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010213-115110"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0015060"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.04.010"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1671"},{"key":"e_1_2_14_28_1","first-page":"10","article-title":"Fecundity of paternal and maternal non\u2010parental female relatives of homosexual and heterosexual men","volume":"7","author":"Ciani A. 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