{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:32:39Z","timestamp":1790163159212,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,3]],"date-time":"2017-09-03T00:00:00Z","timestamp":1504396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"United States National Institute of Health","award":["R01 AI101112"],"award-info":[{"award-number":["R01 AI101112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evolutionary Applications"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effective population size (<jats:italic>N<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub>) is a fundamental parameter in population genetics that determines the relative strength of selection and random genetic drift, the effect of migration, levels of inbreeding, and linkage disequilibrium. In many cases where it has been estimated in animals, <jats:italic>N<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub> is on the order of 10%\u201320% of the census size. In this study, we use 12 microsatellite markers and 14,888 single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) to empirically estimate <jats:italic>N<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub> in <jats:italic>Aedes aegypti<\/jats:italic>, the major vector of yellow fever, dengue, chikungunya, and Zika viruses. We used the method of temporal sampling to estimate <jats:italic>N<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub> on a global dataset made up of 46 samples of <jats:italic>Ae.\u00a0aegypti<\/jats:italic> that included multiple time points from 17 widely distributed geographic localities. Our <jats:italic>N<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub> estimates for <jats:italic>Ae.\u00a0aegypti<\/jats:italic> fell within a broad range (~25\u20133,000) and averaged between 400 and 600 across all localities and time points sampled. Adult census size (N<jats:sub>c<\/jats:sub>) estimates for this species range between one and five thousand, so the <jats:italic>N<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub>\/<jats:italic>N<\/jats:italic><jats:sub><jats:italic>c<\/jats:italic><\/jats:sub> ratio is about the same as for most animals. These <jats:italic>N<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub> values are lower than estimates available for other insects and have important implications for the design of genetic control strategies to reduce the impact of this species of mosquito on human health.<\/jats:p>","DOI":"10.1111\/eva.12508","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T13:26:34Z","timestamp":1498224394000},"page":"1031-1039","source":"Crossref","is-referenced-by-count":49,"title":["Effective population sizes of a major vector of human diseases, <i>Aedes aegypti<\/i>"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-0301","authenticated-orcid":false,"given":"Norah P.","family":"Saarman","sequence":"first","affiliation":[{"name":"Yale University  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gloria\u2010Soria","sequence":"additional","affiliation":[{"name":"Yale University  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Fisheries Ecology Division Southwest Fisheries Science Center National Marine Fisheries Service and University of California  Santa Cruz CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Evans","sequence":"additional","affiliation":[{"name":"Yale University  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evlyn","family":"Pless","sequence":"additional","affiliation":[{"name":"Yale University  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano V.","family":"Cosme","sequence":"additional","affiliation":[{"name":"Yale University  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Gonzalez\u2010Acosta","sequence":"additional","affiliation":[{"name":"Centro Nacional de Programas Preventivos y Control de Enfermedades  Ciudad de M\u00e9xico CDMX Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basile","family":"Kamgang","sequence":"additional","affiliation":[{"name":"LSTM\/OCEAC Research Unit Organisation de Coordination pour la lutte contre les End\u00e9mies en Afrique Centrale  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Wesson","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine Tulane University  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Powell","sequence":"additional","affiliation":[{"name":"Yale University  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.038349"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2010.2469"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003864"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122-008-0801-8"},{"key":"e_1_2_9_6_1","volume-title":"Aedes aegypti, the Yellow Fever mosquito","author":"Christophers R.","year":"1960"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.12157"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2311.1984.tb00859.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1603\/ME10264"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.114.016196"},{"key":"e_1_2_9_11_1","first-page":"164","article-title":"PHYLIP \u2010 Phylogeny Inference Package (Version 3.2)","volume":"5","author":"Felsenstein J.","year":"1989","journal-title":"Cladistics"},{"key":"e_1_2_9_12_1","unstructured":"Felsenstein J.(2005).PHYLIP (Phylogeny Inference Package) version 3.6. 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